Amino functional alkoxysilanes

Endpoint summary

Additional information

There are no measured data for the registration substance as a whole. However, according to REACH Annex XI the short-term aquatic toxicity studies do not need to be conducted because the data requirements for these endpoints have been addressed using measured data for the constituents of the substance or for appropriate structural analogues.

All results below are given in terms of the effect concentrations of parent substance as tested. For PNEC derivation and within the individual endpoint summaries, the results have been re-calculated as the equivalent concentration of the silanol hydrolysis product, to which the test organisms were exposed (in addition to ethanol or methanol), based on relative molecular weights. Refer to each endpoint for further explanation.

The relevant values are:

Short-term toxicity to fish

Silanol HP-X - read-across from triethoxy(methyl)silane (CAS 2031-67-6): 96 hour LC₅₀: >500 mg/l, mortality of Danio rerio;

Silanol HP-W and HP-Y - read-across from 3-(trimethoxysilyl)-N-[3-(trimethoxysilyl)propyl]-1-propanamine (CAS 82985-35-1): 96 hour LC₅₀: 130 mg/l, mortality of Oncorhynchus mykiss;

Silanol HP-W and HP-Y - read-across from 3-(trimethoxysilyl)-N-[3-(trimethoxysilyl)propyl]-1-propanamine (CAS 82985-35-1): 96 hour LC₅₀: >100 mg/l, mortality of Oryzias latipes;

Silanol HP-W and HP-Y - read-across from N,N-bis(3-triethoxysilylpropyl)amine (CAS 13497-18-2): 96 hour LC₅₀: >200 mg/l, mortality of Scophthalmus maximus (read-across from CAS 13497-18-2);

Silanol HP-Z - read across from 3-aminopropyl(triethoxy)silane (CAS: 919-30-2): 96 hour LC₅₀: >934 mg/l, mortality of Brachydanio rerio.

 

Short-term toxicity to aquatic invertebrates

Silanol HP-X - read-across from triethoxy(methyl)silane (CAS 2031-67-6): 48 hour EC₅₀: >500 mg/l, mobility of Daphnia magna;

Silanol HP-W and HP-Y - read-across from N,N-bis(3-triethoxysilylpropyl)amine (CAS 13497-18-2): 48 hour LC₅₀: >200 mg/l, mortality of Acartia tonsa (Dana);

Silanol HP-W and HP-Y - read-across from 3-(trimethoxysilyl)-N-[3-(trimethoxysilyl)propyl]-1-propanamine (CAS 82985-35-1): 48 hour EC₅₀: >100 mg/l, mobility of Daphnia magna;

Silanol HP-Z - read across from 3-aminopropyl(triethoxy)silane (CAS 919-30-2): 48 hour EC₅₀: 331 mg/l, mobility of Daphnia magna.

 

Toxicity to aquatic algae

Silanol HP-X - read-across from triethoxy(methyl)silane (CAS 2031-67-6): 72 hour ErC₅₀ >500 mg/l and NOEC ≥500 mg/l, growth rate of Pseudokirchneriella subcapitata;

Silanol HP-X - read-across from trimethoxy(methylsilane) (CAS 1185-55-3): 72 hour ErC₅₀ >120 mg/l and NOEC ≥120 mg/l, growth rate of Pseudokirchneriella subcapitata;

Silanol HP-W and HP-Y - read-across from N,N-bis(3-triethoxysilylpropyl)amine (CAS 13497-18-2): 72 hour ErC₅₀ 125 mg/l, ErC₁₀ 68 mg/l and NOEC 51 mg/l, growth rate of Phaeodactylum tricornutum;

Silanol HP-W and HP-Y - read-across from 3-(trimethoxysilyl)-N-[3-(trimethoxysilyl)propyl]-1-propanamine (CAS 82985-35-1): 72 hour ErC₅₀ 36 mg/l, NOEC 8.3 mg/l, growth rate of Pseudokirchneriella subcapitata;

Silanol HP-Z - read across from 3-aminopropyl(triethoxy)silane (CAS 919-30-2): 72 hour ErC₅₀ >1000 mg/l and ErC₁₀ 321 mg/l, growth rate of Desmodesmus subspicatus.

Silanol HP-Z - read across from 3-aminopropyl(triethoxy)silane (CAS 919-30-2): 72 hour ErC₅₀ 863 mg/l and NOEC 40 mg/l, growth rate of Skeletonema costatum.

Long-term toxicity to aquatic invertebrates

Silanol HP-X - 21 day NOEC ≥10 mg/l was determined for the effects of methylsilanetriol on mortality, reproduction and growth of Daphnia magna.

Silanol HP-Z - 21 day NOEC ≥1 mg/l was determined for the effects of 3-aminopropylsilanetriol on mortality and reproduction of Daphnia magna.