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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1999

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Qualifier:
according to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(7-ethyl-1H-indol-3-yl)ethanol
EC Number:
431-020-1
EC Name:
2-(7-ethyl-1H-indol-3-yl)ethanol
Cas Number:
41340-36-7
Molecular formula:
C12H15NO
IUPAC Name:
2-(7-ethyl-1H-indol-3-yl)ethan-1-ol

Test animals

Species:
rat
Strain:
Wistar

Administration / exposure

Vehicle:
polyethylene glycol

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 200 - < 2 000 mg/kg bw
Mortality:
Male: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 2
Clinical signs:
Signs of toxicity related to dose levels:
Mortality:
Two females treated with 2000 mg/kg were found dead on test
day 2. All other animals survived until scheduled necropsy.
Clinical signs:
In all animals, treated with 2000 mg/kg, ataxia and sedation
were observed on test day 1. In two animals, ruffled fur was
evident and persisted in one animal until test day 6. In one
female, irregular respiration and ventral position were
noted before it was found dead. No clinical signs were
observed in all animals, treated at a dose level of 200
mg/kg.
Body weights:
The body weight of the surviving animals was within the
range commonly recorded for animals of this strain and age.
Gross pathology:
Effects on organs:
No macroscopic findings were observed at necropsy.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU