Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sensitisation data (humans)
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined. Insufficient data documentation.

Data source

Reference
Reference Type:
publication
Title:
Studies on the toxicity and skin effects of compounds used in the rubber and plastics industries
Author:
Mallette F.S., von Haam E.
Year:
1952
Bibliographic source:
Arch. Hyg. Occup. Med. 6, 231-236 (1952)

Materials and methods

Type of sensitisation studied:
skin
Study type:
other: human subjects
Principles of method if other than guideline:
Sensitization toxicity in human
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of 3-methylphenyl diphenyl phosphate, 4-methylphenyl diphenyl phosphate, bis(3-methylphenyl) phenyl phosphate, 3-methylphenyl 4-methylphenyl phenyl phosphate and triphenyl phosphate
Molecular formula:
3-methylphenyl diphenyl phosphate: C19H17O4P 4-methylphenyl diphenyl phosphate´: C19H17O4P triphenyl phosphate: C18H15O4P bis(3-methylphenyl) phenyl phosphate: C20H19O4P 3-methylphenyl 4-methylphenyl phenyl phosphate: C20H19O4P
IUPAC Name:
Reaction mass of 3-methylphenyl diphenyl phosphate, 4-methylphenyl diphenyl phosphate, bis(3-methylphenyl) phenyl phosphate, 3-methylphenyl 4-methylphenyl phenyl phosphate and triphenyl phosphate
Constituent 2
Reference substance name:
chemical name: Diphenyl tolyl phosphate MCS
IUPAC Name:
chemical name: Diphenyl tolyl phosphate MCS
Details on test material:
Santicizer 140= monotolyldiphenyl phosphate

Method

Type of population:
not specified
Controls:
no data
Route of administration:
dermal

Results and discussion

Any other information on results incl. tables

The test substance was not found to have a sensitizing effect.

Applicant's summary and conclusion

Executive summary:

In a patch test the test substance was tested in 15 -30 human subjects. Sensitation tests were performed two weeks after the primary irritation test. The test substance was not found to have a sensitizing effect.