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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
other: EU method A.7
Version / remarks:
as cited in 84/449/EEC
GLP compliance:
yes
Key result
Medium:
standard fat
Solubility:
139.2 mg/100 g solvent
Temp.:
37 °C
Test substance stable:
not determined
Conclusions:
The test substance has a solubility in standard fat of 139.2 mg/100 g solvent at 37 °C.
Executive summary:

The fat solubility was determined according to EU method A.7 as cited in Commission Directive 84 / 449 / EEC adapting Council Directive 67/548/EEC (Huntingdon, ECHA RSS, 2017). A solubility of 138.2 mg/100 g solvent at 37 °C in standard fat HB 307 was measured for the test substance.

Description of key information

139.2 mg/100 g standard fat at 37 °C

Key value for chemical safety assessment

Solubility in mg/100g standard fat:
139.2
At the temperature of:
37 °C

Additional information

In accordance with Article 25(3) of the REACH Regulation the robust study summaries submitted 12 years previously, are used for the purpose of the registration.

In a key study according to EU method A.7 (as cited in Commission Directive 84/449/EEC), the test substance showed a solubility of 139.2 mg/100 g in standard fat at 37 °C (Huntingdon, ECHA RSS, 2017). In a supporting study, a solubility in standard fat of 144 mg/100 g at 37 °C was determined (Safepharm, ECHA RSS, 2017).