Registration Dossier
Registration Dossier
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EC number: 701-188-3 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- Not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- BCF value calculated by using a QSAR Method
- Justification for type of information:
- The provided data is QSAR data. The study report is provided as justification.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Calculations based on structure activity.
- GLP compliance:
- no
- Remarks:
- (not applicable)
- Radiolabelling:
- no
- Details on sampling:
- not applicable
- Details on preparation of test solutions, spiked fish food or sediment:
- not applicable
- Test organisms (species):
- no data
- Details on test organisms:
- No data
- Route of exposure:
- other: QSAR
- Test type:
- other: QSAR
- Water / sediment media type:
- not specified
- Hardness:
- not applicable
- Test temperature:
- not applicable
- pH:
- not applicable
- Dissolved oxygen:
- not applicable
- TOC:
- not applicable
- Salinity:
- not applicable
- Details on test conditions:
- not applicable
- Nominal and measured concentrations:
- not applicable
- Reference substance (positive control):
- not required
- Remarks:
- QSAR
- Details on estimation of bioconcentration:
- not applicable
- Key result
- Type:
- BCF
- Value:
- 65.21 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Arnot-Gobas lower trophic (including biotransformation), BCFBAF v3.01 (logKow = 4.41)
- Details on kinetic parameters:
- no data
- Metabolites:
- no data
- Results with reference substance (positive control):
- no data
- Details on results:
- no data
- Reported statistics:
- no data
- Validity criteria fulfilled:
- yes
- Conclusions:
- BCF value of terpineol is 65.21 L/kg wet-wt using Arnot-Gobas approach.
- Executive summary:
BCF value of terpineol has been assessed under BCFBAF v3.01 software.
The result for the Arnot-Gobas upper trophic approach (including no biotransformation) is the following:
BCF (L/kg) = 65.21.
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- Not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- BCF value calculated by using a QSAR Method
- Justification for type of information:
- The provided data is QSAR data. The study report is provided as justification.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Calculations based on structure activity.
- GLP compliance:
- no
- Remarks:
- (not applicable)
- Radiolabelling:
- no
- Details on sampling:
- not applicable
- Details on preparation of test solutions, spiked fish food or sediment:
- not applicable
- Test organisms (species):
- no data
- Details on test organisms:
- No data
- Route of exposure:
- other: QSAR
- Test type:
- other: QSAR
- Water / sediment media type:
- not specified
- Hardness:
- not applicable
- Test temperature:
- not applicable
- pH:
- not applicable
- Dissolved oxygen:
- not applicable
- TOC:
- not applicable
- Salinity:
- not applicable
- Details on test conditions:
- not applicable
- Nominal and measured concentrations:
- not applicable
- Reference substance (positive control):
- not required
- Remarks:
- QSAR
- Details on estimation of bioconcentration:
- not applicable
- Key result
- Type:
- BCF
- Value:
- 33.29 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: regression-based estimate, BCFBAF v3.01
- Details on kinetic parameters:
- no data
- Metabolites:
- no data
- Results with reference substance (positive control):
- no data
- Details on results:
- no data
- Reported statistics:
- no data
- Validity criteria fulfilled:
- yes
- Conclusions:
- BCF value of terpineol is 33.29 L/kg wet-wt with the regression-based approach.
- Executive summary:
BCF value of terpineol has been assessed by using BCFBAF v3.01 software.
The results with the regression-based estimate approach (including biotransformation) is as following: BCF (L/kg) = 33.29.
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- Terpinolene is an impurity of multiconstituent substance TERPINEOL MULTICONSTITUENT. Data on terpinolene are used as worst case data, in comparison with the main constituents of TERPINEOL MULTICONSTITUENT.
- Reason / purpose for cross-reference:
- read-across source
- Type:
- other: log BCF
- Value:
- 2.524 dimensionless
- Remarks on result:
- other: regression-based estimate, BCFBAF v3.01
- Key result
- Type:
- BCF
- Value:
- 334.1 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: regression-based estimate, BCFBAF v3.01
- Details on kinetic parameters:
- no data
- Metabolites:
- no data
- Results with reference substance (positive control):
- no data
- Details on results:
- no data
- Reported statistics:
- no data
- Validity criteria fulfilled:
- yes
- Conclusions:
- BCF value of CAS 586-62-9 is 334.0 L/kg wet-wt.
- Executive summary:
BCF value of CAS 586-62-9 has been assessed by using BCFBAF v3.01 software.
The results with the regression-based estimate approach is as following:
- log BCF = 2.524 , BCF (L/kg) = 334.0
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- Terpinolene is an impurity of multiconstituent substance TERPINEOL MULTICONSTITUENT. Data on terpinolene are used as worst case data, in comparison with the main constituents of TERPINEOL MULTICONSTITUENT.
- Reason / purpose for cross-reference:
- read-across source
- Type:
- other: Log BCF
- Value:
- 2.913 dimensionless
- Remarks on result:
- other: Arnot-Gobas lower trophic (including biotransformation), BCFBAF v3.01 (logKow = 4.33)
- Key result
- Type:
- BCF
- Value:
- 818.4 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Arnot-Gobas lower trophic (including biotransformation), BCFBAF v3.01 (logKow = 4.33)
- Details on kinetic parameters:
- no data
- Metabolites:
- no data
- Results with reference substance (positive control):
- no data
- Details on results:
- no data
- Reported statistics:
- no data
- Validity criteria fulfilled:
- yes
- Conclusions:
- BCF value of CAS 586-62-9 is 818.4 L/kg wet-wt.
- Executive summary:
BCF value of CAS 586-62-9 has been assessed under BCFBAF v3.01 software.
The results for the Arnot-Gobas lower trophic (including biotransformation) approach are as following:
- log BCF = 2.913, BCF (L/kg) = 818.4
Referenceopen allclose all
No additional information.
No additional information.
Information for approaches from BCFBAF v3.01 software are given through attached files (QMRF and QPRF).
Information for approaches from BCFBAF v3.01 software are given through attached files (QMRF and QPRF).
Description of key information
The bioconcentration factor (BCF) was
estimated by two QSAR models:
- BCFBAF v3.01 module of EPI Suite (v4.0) - Regression-based estimate
- BCF-BAF v3.01 module of EPI Suite (v4.0) (including biotransformation)
- Arnot-Gobas lower trophic level
The estimated fish BCF of terpineol multiconstituent selected for risk assessment is the worst case value of 65.21 L/kg which does not take into account any biotransformation.
Data on terpinolene, one impurity of substance terpineol multiconstituent, are presented as worst case values for the chemical safety assessment.
Key value for chemical safety assessment
- BCF (aquatic species):
- 65.21 L/kg ww
Additional information
The estimated fish BCF selected for terpineol multiconstituent is the worst case value of 65.21 L/kg which does not take into account any biotransformation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
