Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 700-150-3 | CAS number: 156572-81-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance has a high surface activity
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- EPI Suite Calculation
- GLP compliance:
- no
- Type of method:
- other: Calculation
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.832
- Temp.:
- 25 °C
- pH:
- ca. 7
Referenceopen allclose all
Description of key information
End point waived as testing scientifically not feasible due to surface active properties of the substance. EPISuite calculated Log Kow value of 0.832 is used for CSA purposes only
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.832
- at the temperature of:
- 25 °C
Additional information
Sodium Lauryl Methyl Isethionate (SLMI) is an Anionic Surface Acting Agent. This therefore affects the results of the Octanol-Water Partition Coefficient test, due to the emulsion that forms at the partition interface. Surface acting agents have the ability of altering the surface or interfacial energies of two immiscible phases, thus skewing the results of testing.
According to OECD Testing Guidelines for Test Method 117 Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography Method isn’t applicable for surface-active agents.
According to OECD Testing Guidelines for Test Method 107, the Shake Flask method is impossible to use with surface-active agents.
According to OECD Testing Guidelines for Test Method 123, Partition Coefficient (1-Octanol/Water), Slow Stirring method is not applicable for substances that display significant interfacial activity. So, as with the Shake Flask method and due to the properties of SLMI, coupled with its foaming capabilities it would impossible to separate the two immiscible solvents at the interface to obtain reliable results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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