Registration Dossier
Registration Dossier
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EC number: 821-951-5 | CAS number: 9032-14-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
The present target substance, dextransucrase IUBMB 2.4.1.5, has been investigated in the Ames test and in the in vitro chromosome aberration test. Both tests have been performed according to current OECD guidelines, and in compliance with GLP. No evidence for genetic toxicity was observed.
These results are supported by read-across from 2 in vitro gene mutation studies in L5178Y mouse lymphoma cells performed on two different amylases belonging to the class of glycosidases (IUBMB class 3.2.1.).
The conclusion is that the target substance dextransucrase IUBMB 2.4.1.5 is considered to be non-mutagenic.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
Due to the lack of genetic toxicity dextransucrase is not classified.
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