Cadmium sulfoselenide

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vitro / ex vivo

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Test according to state-of-the-art operating procedures for testing of metal bioelution.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: ASTM D5517-07: Standard Test Method for determining the extractability of metals from art materials - ASTM, 2007 (American Society for Testing and Materials).

Principles of method if other than guideline:

The release/dissolution of cadmium from cadmium telluride in simulated gastric fluid was measured. The resulting value is termed bio-accessibility, and is defined as the fraction of a substance that is soluble under physiological conditions and therefore potentially available for absorption into systemic circulation. The simulated gastric fluid represents an exposure-relevant exposure route (oral exposure). The compound was introduced as powder in a test item / solution ratio of 200 mg/L during 2 hours.

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Cadmium telluride

EC Number:

215-149-9

EC Name:

Cadmium telluride

Cas Number:

1306-25-8

Molecular formula:

CdTe

IUPAC Name:

telluroxocadmium

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Physical state: powder, dark grey
- Purity: 99.999% CdTe
- Lot/batch No.: 166386
- Expiration date of the lot/batch: stable over time
- Storage condition of test material: room temperature, in the dark, under argon atmosphere
- Particle size (typical): 200 mesh (74µm)

Test animals

Details on test animals or test system and environmental conditions:

not applicable

Administration / exposure

Details on exposure:

not applicable

Results and discussion

Preliminary studies:

not applicable

Main ADME results

Type:

other: bioaccessibility

Results:

gastric fluid (2hours) as %Cd released of total Cd content: average : 35.35 ± 8.69

Toxicokinetic / pharmacokinetic studies

Details on absorption:

not applicable

Details on distribution in tissues:

not applicable

Details on excretion:

not applicable

Bioaccessibility (or Bioavailability)

Bioaccessibility (or Bioavailability) testing results:

gastric bioaccessibility (2hours) as %Cd released of total Cd content: average : 35.35 ± 8.69 (experiment 1: 29.2, experiment 2: 41.5)

Any other information on results incl. tables

Experiment 1

cadmium telluride, loading 0.2 g/L              2h gastric at pH 1.5
Analyte                                                              X±σ                        CV
Cadmium (Cd)	dissolution	27394±3527 µg/L	13%
	eluted	136675±17442 µg/g	13%
% Cadmium eluted		29.2 %

X= Average of 3 test vessels (0.2µm filtration)

σ = Standard deviation

CV: Coefficient of variation (%)

Experiment 2

cadmium sulfoselenide red, loading 0.2 g/L              2h gastric at pH 1.5
Analyte                                                              X±σ                        CV
Cadmium (Cd)	dissolution	38953±3953 µg/L	10%
	eluted	194391±19494 µg/g	10%
% Cadmium eluted		41.5 %

X= Average of 3 test vessels (0.2µm filtration)

σ = Standard deviation

CV: Coefficient of variation (%)

 

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): other: Moderate bioaccessibility of Cd2+ from CdTe. The data have been incorporated into read-across assessment. The dissolution in gastric fluid is used to estimate bioavailability after oral exposure
Bio-elution test according to state-of-the-art procedures, useful for determining dissolution capacity of Cd in gastric fluid.

Executive summary:

During this study on Cadmium telluride at a loading of 0.2 g/L in simulated gastric fluid (pH 1.5), it was shown that significant amounts of cadmium were measured. For cadmium an average value of 27394 μg/L Cd (CV = 13%) and 38953 μg/L Cd (CV = 10%) were found in a first and second experiment, respectively, after 2 hours of extraction. This corresponds with cadmium releases of 29.2% and 41.5%, respectively.