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EC number: 200-469-3 | CAS number: 60-32-2
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2017-06-30 to 2017-07-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C.
- for 20 °C: 3.648E-12 Pa
- for 25 °C: 2.615E-11 Pa - Executive summary:
A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 in order to determine the vapour pressure of the test item. The vapour pressure was determined at temperatures from 40 to 130 °C using the effusion method (Knudsen cell). The used temperatures were below the melting point range of the test item (204 to 205 °C according to literature). For the evaluation the vapour pressure values in the range of 80 to 120 °C were used. The vapour pressure of the test item was determined by extrapolation of the measured vapour pressure curve for the temperatures 20 °C with 3.648 x 10-12 Pa and 25 °C with 2.615 x 10-11 Pa.
Reference
The vapour pressure was measured in the temperature range of 40 to 130 °C. For the evaluation the vapour pressure values in the range of 80 to 120 °C were used. The measured vapour pressure values together with the measured temperatures are listed in Table 1.
Table 1: Results of Effusion method
| Stage no. | Temperature (°C) |
Δm/Δt (mg/min) |
Vapour pressure (Pa) |
| 1 | 80 | 4.6729 x 10-6 | 1.3335 x 10-3 |
| 2 | 90 | 9.4595 x 10-5 | 2.7373 x 10-2 |
| 3 | 100 | 1.4116 x 10-3 | 4.1407 x 10-1 |
| 4 | 110 | 1.3628 x 10-2 | 4.0507 |
| 5 | 120 | 8.5632 x 10-2 | 25.783 |
Description of key information
The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C.
- for 20 °C: 3.648 x 10-12 Pa
- for 25 °C: 2.615 x 10-11 Pa
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 in order to determine the vapour pressure of the test item. The vapour pressure was determined at temperatures from 40 to 130 °C using the effusion method (Knudsen cell). For the evaluation the vapour pressure values in the range of 80 to 120 °C were used. The melting range of the test item was 204 to 205 °C according to literature. The vapour pressure of the test item was determined by extrapolation of the measured vapour pressure curve for the temperatures 20 °C with 3.648 x 10-12 Pa and 25 °C with 2.615 x 10-11 Pa (reference 4.6-1).
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