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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Justification for type of information:
xxxx
See attached document in section 13

Data source

Reference
Reference Type:
other: SISD Assessment report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EPA OTS 798.1150 (Acute inhalation toxicity)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzoic acid
EC Number:
200-618-2
EC Name:
Benzoic acid
Cas Number:
65-85-0
Molecular formula:
C7H6O2
IUPAC Name:
benzoic acid
Test material form:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
Ten rats (4 units of 2 or 3 rats/unit to prevent piling) were placed in a sealed 59.1 liter glass chamber and exposed to a dynamic atmosphere containing the dust of the test material. A Wright Dust Feeder controlled addition of the test substance; airflow regulated by a flowmeter. The rats were observed continuously during the 4-hour exposure, and for a period of 14 days following exposure.

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
The rats were placed in a sealed 59.1 liter glass chamber and exposed to a dynamic atmosphere containing the dust of the test material. A Wright Dust Feeder controlled addition of The test substance; airflow regulated by a flowmeter.
Duration of exposure:
4 h
No. of animals per sex per dose:
10 rats (2-3 rats per unit)
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
12.2 mg/L air
Exp. duration:
4 h
Mortality:
All rats survived the 4-hour exposure and the 14-day observation period.
Clinical signs:
other: Signs during the exposure period included occasional increased motor activity and slight erythema. At the conclusion of exposure, 1 rat exhibited salivation.
Body weight:
At 24 hours and through the 14-day observation period, all rats appeared normal and exhibited normal body weight gains.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

Ten rats (4 units of 2 or 3 rats/unit to prevent piling) were placed in a sealed 59.1 liter glass chamber and exposed to a dynamic atmosphere containing the dust of the benzoic acid by Wright Dust Feeder controlled system and airflow regulated by a flowmeter. The rats were observed continuously during the 4-hour exposure, and for a period of 14 days following exposure. All of the rats survived the 4-hour exposure and the 14-day observation period. Signs during the exposure period included occasional increased motor activity and slight erythema. At the conclusion of exposure, 1 rat exhibited salivation. At 24 hours and through the 14-day observation period, all rats appeared normal and exhibited normal body weight gains.