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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Justification for type of information:
Study is referenced in OECD SIDS report, ref 73: Angenelli et al 1985

Data source

Reference
Reference Type:
other: SISD Assessment report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EPA OTS 798.1100 (Acute Dermal Toxicity)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzoic acid
EC Number:
200-618-2
EC Name:
Benzoic acid
Cas Number:
65-85-0
Molecular formula:
C7H6O2
IUPAC Name:
benzoic acid
Test material form:
not specified

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male/female

Administration / exposure

Details on dermal exposure:
The test compound was applied once only to a shaved area of the back of each rabbit at a dose of 2000 mg/kg bw.
Duration of exposure:
24 h
Doses:
2000 mg/kg/day
No. of animals per sex per dose:
4
Control animals:
not specified
Details on study design:
The test compound was applied once only to a shaved area of the back of each rabbit at a dose of 2000 mg/kg bw.
The skin of 1 male and 1 female was abraded with a scalpel blade prior to test application.
The area was wrapped with a gauze bandage and occluded with plastic wrap. The bandages were removed and the backs washed
24 hours after application. The rabbits were observed for a period of 14 days.

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute dermal toxicity of benzoic acid was determined according to the method EPA OTS 798.1100. LD50 of benzoic acid was found to be > 2000 mg/kg/day for acute dermal toxicity
Executive summary:

The acute dermal toxicity of benzoic acid was determined according to the method EPA OTS 798.1100.

The test compound was applied once only to a  shaved area of the back of each rabbit at a dose of 2000 mg/kg bw. The skin of 1 male and 1 female was abraded with a scalpel blade prior to test application. The area was wrapped with a gauze bandage and occluded with plastic wrap. The bandages were removed and the backs washed

24 hours after application. The rabbits were observed for a period of 14 days.

LD50 was found to be > 2000 mg/kg/day for acute dermal toxicity