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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Justification for type of information:
The study is from the RAC oppinion of Benzoic acid and is indicated as the most reliable study on sensitisation. RAC oppinion reffering to data from Gerberick et al Toxicol 19:438-445 (1992).

Data source

Reference
Reference Type:
other: RAC oppinion
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
no
Remarks:
Study was performed before 1. of June 2008
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzoic acid
EC Number:
200-618-2
EC Name:
Benzoic acid
Cas Number:
65-85-0
Molecular formula:
C7H6O2
IUPAC Name:
benzoic acid
Test material form:
not specified

In vivo test system

Test animals

Species:
mouse
Strain:
CBA:J
Sex:
female

Study design: in vivo (LLNA)

Vehicle:
other: acetone
No. of animals per dose:
5

Results and discussion

In vivo (LLNA)

Results
Key result
Parameter:
other: Not indicated
Value:
0
Test group / Remarks:
0/5 animals were sensitized
Remarks on result:
other:
Remarks:
Negative. The substance is not sensitising

Any other information on results incl. tables

No information on SI or EC3 is available

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Benzoic acid is not sensitising
Executive summary:

The sensitizing activity of benzoic acid was tested in LLNA (Non-GLP, sim. to OECD 429) in CBA/J mice. Benzoic acid was dissolved in acetone. 0 out of 5 mice was senstised. The test was negative and showed that benzoic acid was not sensitising.