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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
genetic toxicity in vitro, other
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
other: SISD Assessment report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 479 (Genetic Toxicology: In Vitro Sister Chromatid Exchange Assay in Mammalian Cells)
GLP compliance:
not specified
Type of assay:
sister chromatid exchange assay in mammalian cells

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzoic acid
EC Number:
200-618-2
EC Name:
Benzoic acid
Cas Number:
65-85-0
Molecular formula:
C7H6O2
IUPAC Name:
benzoic acid
Test material form:
not specified

Method

Species / strain
Species / strain / cell type:
lymphocytes: human
Metabolic activation:
without
Test concentrations with justification for top dose:
0 to 2.0 mM

Results and discussion

Test results
Key result
Species / strain:
lymphocytes: human
Metabolic activation:
without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Conclusions:
The genotixicity of benzoic acid was tested in human lymphocytes by sister cromatid exhange assay according to OECD 479. Doses from 0 to 2 mM was tested without metabolic activation. No genotoxicty was observed. The study is described in SIDS (2001)
Executive summary:

The genotixicity of benzoic acid was tested in human lymphocytes by sister cromatid exhange assay according to OECD 479. Doses from 0 to 2 mM was tested without metabolic activation. No genotoxicty was observed. The study is described in SIDS (2001)