Registration Dossier
Registration Dossier
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EC number: 268-387-0 | CAS number: 68083-38-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.6 (Skin Sensitisation)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of study:
- Buehler test
Test material
- Reference substance name:
- m-(4,5-dihydro-5-imino-3-methyl-1H-pyrazol-1-yl)benzenesulphonic acid
- EC Number:
- 268-387-0
- EC Name:
- m-(4,5-dihydro-5-imino-3-methyl-1H-pyrazol-1-yl)benzenesulphonic acid
- Cas Number:
- 68083-38-5
- Molecular formula:
- C10H11N3O3S
- IUPAC Name:
- 3-(5-imino-3-methyl-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: albino
- Sex:
- not specified
Study design: in vivo (non-LLNA)
- No. of animals per dose:
- 20 in total
- Positive control substance(s):
- yes
- Remarks:
- formalin
Results and discussion
In vivo (non-LLNA)
Results
- Group:
- test chemical
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In this screening test, performed in twenty albino guinea-pigs, the test substance produced evidence of delayed contact hypersensitivity in all twenty animals and the substance has to be classified accordingly. Due to the insufficient documentation, the reliability of the study and the results cannot be evaluated and hence, the study cannot be used for classification.
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