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EC number: 425-120-4 | CAS number: 83847-14-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Auto flammability
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
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- Endpoint summary
- Stability
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 February - 12 February 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- July 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 425-120-4
- EC Name:
- -
- Cas Number:
- 83847-14-7
- Molecular formula:
- C23H23NO5
- IUPAC Name:
- 4-cyanophenyl 4-{[6-(prop-2-enoyloxy)hexyl]oxy}benzoate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Kißlegg
- Age at study initiation: about 22 weeks
- Weight at study initiation: 3.01 - 3.91 kg
- Housing: separately in special rabbit cages (manufacturer: Becker; type
K99/30 KU, floor area about 5400 cm2
- Diet: ad libitum (Altromin Standard Diet TPF(R) 2113, pellets)
- Water: ad libitum (tap water)
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 22
- Humidity (%): 54 to 75
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Skin alterations, behaviour, and general conditions were observed 1 hour, 24, 48, 72 hours after patch removal, and then daily up to day 8.
Bodey weight was recorded on day 1 and on days 5 and 8. - Number of animals:
- 3 females
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm2
- Type of wrap if used: self-adhesive fabric
REMOVAL OF TEST SUBSTANCE
- Washing: any test material left was wiped off
- Time after start of exposure: 4 hours
OBSERVATION TIME POINTS
Skin alterations, behaviour, and general conditions were observed 1 hour, 24, 48, 72 hours after patch removal, and then daily up to day 8.
Bodey weight was recorded on day 1 and on days 5 and 8.
SCORING SYSTEM:
- Method of calculation: according to DRAIZE scheme and OECD Guideline
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Other effects:
- - Other adverse local effects:
no
- Other adverse systemic effects: no
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the present study, no signs of irritation were seen. Thus, the test item is not considered to be irritating to rabbits' skin.
- Executive summary:
To investigate the potential for primary skin irritation, 0.5 g of the test material were mixed with a few drops of Aqua pro injectione to ensure good contact to the skin, spread onto patches, and then applied to the intact skin of three previously shaven rabbits for a 4 hours period under semiocclusive conditions. The first examination of the treated skin sites followed 1 hour after removal of the patches. Then, examinations were performed daily for another 7 days.
The individual mean scores (considering readings 24, 48, and 72 hours after patch removal) of each animal were 0 for erythema and edema. Furthermore, no signs of systemic toxicity, no mortality and a normal body weight gain were observed.
Under the conditions of the present study, the test item is not considered to be irritating to skin.
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