Registration Dossier
Registration Dossier
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EC number: 267-744-8 | CAS number: 67914-60-7
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 March 2016 - 24 November 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- - Batch n°: I15FB3131
- Analytical purity: 100% (Based on base titration assay)
- Expiration date: 11 June 2017
- Storage condition: at room temperature - Key result
- Melting / freezing pt.:
- 181.8 °C
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- yes
- Remarks:
- A brown molten residue remained after the preliminary and main test, indicating reaction and/or decomposition.
- Decomp. temp.:
- > 350 °C
- Remarks on result:
- other: A brown molten residue remained after the preliminary and main test, indicating reaction.
- Conclusions:
- The melting temperature of JNJ-119379-AAA (T001141) was determined at 181.8°C (454.9K) by using DSC.
Reference
Preliminary test
From the TGA curve it could be derived that the weight of the sample decreased significantly at 375°C. At 405°C the sample weight has decreased by 25%. After the experiment, a dark brown molten residue remained in the sample container (original colour: white). The change of the colour indicated reaction and/or decomposition of the test item.
Main tests
In order to determine the melting more precisely, the DSC curve with a heating rate of 20°C/min was obtained and showed an endothermic peak between 150°C and 200°C. The extrapolated onset temperature of the peak was 181.758°C. The effect was most likely obtained due to melting. Starting at 350°C, the DSC curve showed an endothermic effect. The effect was most likely due to the start of reaction and/or decomposition. After the experiment, a brown molten residue remained in the sample container.
To investigate the melting peak between 150°C and 200°C, a repeated heating cycle was carried out. The extrapolated onset temperature of the melting peak was 181.788°C. The melting temperature of T001141 was determined as the average melting temperature obtained from Experiment 1 and Experiment 2 and equals 181.8°C (454.9K).
Description of key information
Based on the guideline study performed (Klimisch 1, Reingruber, 2016) the melting temperature of JNJ-119379-AAA (T001141) was determined at 181.8°C (454.9K) by using DSC.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 181.8 °C
Additional information
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