Registration Dossier

Physical & Chemical properties

Melting point / freezing point

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 March 2016 - 24 November 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
- Batch n°: I15FB3131
- Analytical purity: 100% (Based on base titration assay)
- Expiration date: 11 June 2017
- Storage condition: at room temperature
Key result
Melting / freezing pt.:
181.8 °C
Atm. press.:
1 013.25 hPa
Decomposition:
yes
Remarks:
A brown molten residue remained after the preliminary and main test, indicating reaction and/or decomposition.
Decomp. temp.:
> 350 °C
Remarks on result:
other: A brown molten residue remained after the preliminary and main test, indicating reaction.

Preliminary test

From the TGA curve it could be derived that the weight of the sample decreased significantly at 375°C. At 405°C the sample weight has decreased by 25%. After the experiment, a dark brown molten residue remained in the sample container (original colour: white). The change of the colour indicated reaction and/or decomposition of the test item.

 

Main tests

In order to determine the melting more precisely, the DSC curve with a heating rate of 20°C/min was obtained and showed an endothermic peak between 150°C and 200°C. The extrapolated onset temperature of the peak was 181.758°C. The effect was most likely obtained due to melting. Starting at 350°C, the DSC curve showed an endothermic effect. The effect was most likely due to the start of reaction and/or decomposition. After the experiment, a brown molten residue remained in the sample container.

To investigate the melting peak between 150°C and 200°C, a repeated heating cycle was carried out. The extrapolated onset temperature of the melting peak was 181.788°C. The melting temperature of T001141 was determined as the average melting temperature obtained from Experiment 1 and Experiment 2 and equals 181.8°C (454.9K).

Conclusions:
The melting temperature of JNJ-119379-AAA (T001141) was determined at 181.8°C (454.9K) by using DSC.

Description of key information

Based on the guideline study performed (Klimisch 1, Reingruber, 2016) the melting temperature of JNJ-119379-AAA (T001141) was determined at 181.8°C (454.9K) by using DSC.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
181.8 °C

Additional information