Registration Dossier
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EC number: 201-851-2 | CAS number: 88-68-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96-h LC50 is 395 mg/L in fish (P. promelas).
Key value for chemical safety assessment
Additional information
The short-term toxicity to fish was examined in two studies.
In the first study groups of 20 fish (P. promelas) were exposed to nominal test concentrations of 0 (control), 184, 283, 436, 670 and 1030 mg/L under static conditions for 96 hours (Brooke et al, 1984). Test concentrations were analytically verified on a daily basis. Average analytical test concentrations were <5, 199, 275, 401, 631 and 920 mg/L. Fish were examined for deaths and general symptoms at regular intervals. Deaths and symptoms were observed at all tested concentrations (except controls) and showed a clear concentration dependence. The percentage of death first exceeded 50% (11/20 animals) at a nominal test concentration of 436 mg/L. Based on these findings the 96 -h LC50 was determined at 395 mg/L (based on nominal test concentrations).
In the second study, which was performed in accordance with DIN 38 412, groups of 10 fish (L. idus) were exposed to the substance at nominal test concentrations of 0 (control), 100, 215, 464 and 1000 mg/L under static conditions for 96 hours (BASF, 1990). No analytical verification of test concentrations was performed. Fish were examined for deaths and general symptoms at regular intervals. At a test concentration of 1000 mg/L all fish died after 24 hours of exposure. No deaths were observed at any of the other concentrations tested. Based on the findings, the 96 -h LC50 value was determined at >464 mg/L.
As both studies are considered to be of equal quality, the lowest effect value of 395 mg/L is used for assessment.
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