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EC number: 282-199-6 | CAS number: 84144-79-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,2-Ethanediamine, N-(2-aminoethyl)-, reaction products with glycidyl tolyl ether
- EC Number:
- 282-199-6
- EC Name:
- 1,2-Ethanediamine, N-(2-aminoethyl)-, reaction products with glycidyl tolyl ether
- Cas Number:
- 84144-79-6
- Molecular formula:
- C14H26N3O2
- IUPAC Name:
- 1,2-Ethanediamine, N-(2-aminoethyl)-, reaction products with glycidyl tolyl ether
- Test material form:
- liquid: viscous
- Details on test material:
- Manufacturer Air Products and Chemicals
Batch # 8418406
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Animals were received from Covance Research Products Inc., Denver, PA, on 11 Jan 2017. Following an acclimation period of at least five days. three healthy New Zealand White rabbits (one male -two females) were selected from a larger group without conscious bias.
The animals were born on 03 Sep 2016 and 10 Sep 2016. The pre-test body weight range was 3.0 -3.2 kg.
The animals were identified by cage notation and a uniquely numbered metal ear tag and individually housed in suspended wire-bottom cages. Absorbent paper bedding was placed beneath the cages and changed at least three times per week. Fresh PMI Rabbit Chow (Diet No.5321) was provided daily. Water was available ad libitum. The animal room, reserved exclusively for rabbits on acute tests, was temperature controlled, had a 12 hour light/dark cycle, and was kept clean and vermin free.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml per site
- Duration of treatment / exposure:
- 1h/4h
- Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- Site Preparation
Approximately 24 hours prior to application of the test article, the dorsal area of the trunk of each animal was clipped free of hair. The prepared site was approximately 10% of the body surface and remained intact.
Dosing
The test article (0.5 ml) was applied dermally to two intact sites per rabbit. The test article was kept in contact with the skin for one hour (site 2) and four hours (site 3) at which time the wrappings were removed.
The test article was dosed by volume, 0.5 ml for one hour (site 2) and four hours (site 3) and placed over a 2 x 3 cm gauze patch. Gentle pressure was applied to aid in the distribution of the test article over the prepared site. The patches were secured with non-irritating tape. The test article was kept in contact with the skin for one and four hours at which time the wrappings and patches were removed. The sites were gently washed with gauze saturated with distilled water. The outline of the dose site was marked using an indelible marker.
Type and Frequency of Observations
The exposure sites were scored for dermal irritation at 1, 24, 48 and 72 hours and on Days 7 and 14. Erythema and edema were scored according to the numerical Draize1 scale below. The skin was also evaluated for ulceration and necrosis or any evidence of tissue destruction. Additional signs were described.
Erythema and Eschar
No erythema 0
Very slight erythema (barely perceptible) 1
Well-defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth) 4
Edema
No edema 0
Very slight edema (barely perceptible) 1
Slight edema (edges of area well-defined by definite raising) 2
Moderate edema (raised approximately 1.0 mm) 3
Severe edema (raised more than 1.0 mm, extending beyond the area of exposure) 4
Body weights were recorded pre-test and at termination.
Animals were observed for mortality, toxicological and pharmacological effects at least once daily. All animals were humanely euthanized with a 1 ml intravenous injection (via the marginal ear vein) of Fatal-Plus® following study termination.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 1 h exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Remarks:
- 1 h exposure
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Remarks:
- 1 h exposure
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- 1 h exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- 1 h exposure
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- 1 h exposure
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2.3
- Max. score:
- 7
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.7
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- 4h exposure
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- not reversible
- Other effects:
- No abnormal physical signs were observed. One animal gained weight and two animal’s weight remained the same by study termination.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- 1,2-Ethanediamine, N-(2-aminoethyl)-, reaction products with glycidyl tolyl is assighend classification for corrosivity Category 1C based on Acute Dermal Corrosion study in Rabbits.
- Executive summary:
Three healthy New Zealand White rabbits (one male - two females) were dosed dermally with 1,2-Ethanediamine, N-(2-aminoethyl)-, reaction products with glycidyl tolyl ether batch 8418406. The test article (0.5 ml) was applied dermally to two intact sites per rabbit. The test article was kept in contact with the skin for one hour (site 2) and four hours (site 3) at which time the wrappings were removed. Erythema and edema were scored at 1, 24, 48 and 72 hours and again on Days 7 and 14. Based on the test results, material is assighend classification for corrosivity Category 1C.
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