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EC number: 240-948-4 | CAS number: 16903-35-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 April 1993 - 14 May 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant. Guideline study (OECD401) however the guideline was deleted in 2002. Available as an unpublished report. Acceptable with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrachloroauric acid
- EC Number:
- 240-948-4
- EC Name:
- Tetrachloroauric acid
- Cas Number:
- 16903-35-8
- Molecular formula:
- AuCl4.H
- IUPAC Name:
- tetrachloroauric acid
- Details on test material:
- - Name of test material (as cited in study report): Tetrachloroauric(III)acid
- Physical state: Yellow, crumble pieces, extremely hygroscopic
- Analytical purity: 99.9% purity of the metal used for production of this compund.
- Lot/batch No.: 64
- Stability under test conditions: Stable
- Storage condition of test material: In ampoules that were welded in a refrigerator
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Bor: WISW (SPFCpb)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann Versuchstierzucht GmbH & Co. KG., D-33176 Borchen
- Age at study initiation: Males: 8 weeks, Females: 9 weeks
- Weight at study initiation: Males: 201 - 224 g, Females: 158 - 179 g
- Fasting period before study: Appox. 16 hours prior to treatment.
- Housing: Macrolon cages, type II
- Diet (e.g. ad libitum): ssniff R, Special diet for rats, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.5 - 22.5 °C
- Humidity (%): 39 - 68%
- Photoperiod (hrs dark / hrs light): 6 a.m. - 6 p.m. CET artifical lighting, 6 p.m. - 6 a.m. CET darkness.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 2.15 mL/kg b.w.
- Doses:
- 215, 464 mg/kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: mortality observed at 0.5, 1, 2, 4, 6, 24 hours and daily thereafter. Body weights recorded at days 0, 7 and 14.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 464 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At the 215 mg/kg b.w. treatment level one female was found dead at 24 hours
At the 464 mg/kg b.w. treatment level four males were found dead at 3 days. - Clinical signs:
- Rats treated with 215 mg/kg bw exhibited slight hypokensia, piloerection, sunken sides, and stilted gait. Females additionally exibited coordination disturbances. One female, later found dead, displayed strenuous respiration. Survivors were observed to recover after 24 hours.
Rats treated with 464 mg/kg b.w. exhibited the above symptoms. Survivors recovered within 3 to 5 days with the exception of one female which had not fully recovered by day 14. - Body weight:
- A reduction in body weight was observed in rats treated with 164 mg/kg b.w.
- Gross pathology:
- See table 1.
Any other information on results incl. tables
Table 1. Results of Macroscopical Examination
Organ/finding | No. of animals at dose | |
215 mg/kg | 464 mg/kg | |
Male surviving animals | ||
Stomach wall: slightly thickened | 0 | 1 |
No abnomalities detected | 5 | 0 |
Male , deceased animals | ||
Forestomach: focal hemorrage | na | 2 |
Stomach: severely distended, glandular stomach: wall hardedned, black-red discoloured, intestine: autolytic | na | 4 |
Female, surviving animals | ||
Stomach wall: slightly thickened | 0 | 5 |
Forestomach: white discoloured | 0 | 1 |
Fusion of the stomach with the liver | 0 | 1 |
No abnomalities detected | 4 | 0 |
Female, deceased animals | ||
Glandular stomach: hardened wall, dark-red discoloured, Stomach:black content, Lung and trachea: no abnormalities detected | na | 1 |
Applicant's summary and conclusion
- Interpretation of results:
- other: No interpretation of the results in presented in the report
- Conclusions:
- In a test where rats were administered with tetrachloroauric acid by gavage at rates of 215 and 464 mg/kg b.w., in neither group was there ≥50% mortality. Therefore the LD50 is determined to be >464 mg/kg b.w. Lethal and sublethal effects were seen at both dose levels which were considered a consequence of the strongly acidic nature of the test solutions.
- Executive summary:
In a GLP-compliant, guideline test where rats were administered with tetrachloroauric acid by gavage at rates of 215 and 464 mg/kg b.w., in neither group was there ≥50% mortality over the course of 14 days. Therefore the LD50 is determined to be >464 mg/kg b.w. Lethal and sublethal effects were seen at both dose levels. The effects seen were considered to be a result of the strongly acidic test substance (pH of test solutions was not neutralised).
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