Registration Dossier
Registration Dossier
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EC number: 249-670-8 | CAS number: 29508-47-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative databases
Data source
Reference
- Reference Type:
- other: Authoritative database
- Title:
- GESTIS for the CAS: 103-83-3
- Author:
- IFA (GESTIS)
- Year:
- 2 017
- Bibliographic source:
- GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften), 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess ocular irritation potential of benzyldimethylamine in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzyldimethylamine
- EC Number:
- 203-149-1
- EC Name:
- Benzyldimethylamine
- Cas Number:
- 103-83-3
- Molecular formula:
- C9H13N
- IUPAC Name:
- Benzyldimethylamine
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Benzyldimethylamine
- Molecular formula: C9H13N
- Molecular weight : 135.209 g/mol
- InChI: 1S/C9H13N/c1-10(2)8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3
- Substance Type: Organic
- Physical State: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Benzyldimethylamine
- Molecular formula:C9H13N
- Molecular weight :135.209 g/mol
- InChI: 1S/C9H13N/c1-10(2)8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3
- Substance Type: Organic
- Physical State:Liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Five μl
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours till 7 days
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Inflammation of the conjunctiva and the iris in rabbit eyes after an exposure period of 24 hours, accompanied by a severe damage of large areas of the cornea was observed in the test animals.
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Inflammation of the conjunctiva and the iris in rabbit eyes after an exposure period of 24 hours, accompanied by a severe damage of large areas of the cornea was observed in the test animals. These effects were completely reversible in 7 days.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- Inflammation of the conjunctiva and the iris in rabbit eyes after an exposure period of 24 hours, accompanied by a severe damage of large areas of the cornea was observed in the test animals. These effects were completely reversible in 7 days.
Since the effects were fully reversible, benzyldimethylamine can be considered to be not irritating to eyes. - Executive summary:
The ocular irritation potential of Benzyldimethylamine was assessed in Rabbits.
Five μl of the test chemical was instilled in the conjunctival sac of the rabbits (number not mentioned) for 24 hours. The animals were observed for signs of irritation till 7 days.
Inflammation of the conjunctiva and the iris in rabbit eyes after an exposure period of 24 hours, accompanied by a severe damage of large areas of the cornea was observed in the test animals. These effects were completely reversible in 7 days.
Since the effects were fully reversible, benzyldimethylamine can be considered to be not irritating to eyes.
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