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Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
INITIAL SUBMISSION:TOXICITY STUDY
Author:
National Technical Reports Library
Year:
1992
Bibliographic source:
INITIAL SUBMISSION

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute oral toxicity of Methyltriphenylphosphonium bromide (CAS no: 1779-49-3) in rats.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyltriphenylphosphonium bromide
EC Number:
217-218-9
EC Name:
Methyltriphenylphosphonium bromide
Cas Number:
1779-49-3
Molecular formula:
C19H18P.Br
IUPAC Name:
Methyltriphenylphosphonium bromide
Details on test material:
Name - Methyltriphenylphosphonium bromide
InChI: 1S/C19H18P.BrH/c1-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19;/h2-16H,1H3;1H/q+1;/p-1
Smiles:[P+](c1ccccc1)(c1ccccc1)(c1ccccc1)C.[BrH-]
- Molecular formula (if other than submission substance):C19H18BrP
- Molecular weight (if other than submission substance):357.229 g/mole
- Substance type:Organic
Specific details on test material used for the study:
Name - Methyltriphenylphosphonium bromide
InChI: 1S/C19H18P.BrH/c1-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19;/h2-16H,1H3;1H/q+1;/p-1
Smiles:[P+](c1ccccc1)(c1ccccc1)(c1ccccc1)C.[BrH-]
- Molecular formula (if other than submission substance):C19H18BrP
- Molecular weight (if other than submission substance):357.229 g/mole
- Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 10%
Doses:
Range of 50-800 mg/kg
No. of animals per sex per dose:
Total = 20
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Other examinations performed: Animals were observed for mortality, clinical signs and body weight change.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
approximate LD50
Effect level:
118 mg/kg bw
Based on:
test mat.
95% CL:
84 - 167
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at 118 mg/kg bw
Clinical signs:
Clinical signs were observed in treated rats.
At 50 mg/kg symptoms like diarrhea was observed in 2-4 hr. which was normal within 24 hr.
At 100 mg/kg symptoms like diarrhea was observed in 2-4 hr.
At the range of 200-800 mg/kg: Tremors, convulsions, diarrhea and death within 24 hr was observed.
Body weight:
Weight change was observed in animals.
Gross pathology:
not specified
Other findings:
not specified

Any other information on results incl. tables

Table: Acute oral toxicity of Methyltriphenylphosphonium Bromide

Solution

Animals* No. and Species

Route**

Dose Range

mg/kg

Approx.

LD50***

mg/kg

Symptoms

Time of death

Weight change 2 wks

Acute Toxicity

10% in H2O

20R

PO

50-800

118

84-167

50 mg/kg: Sl. to mod. w., some diarrhea 2-4 hr., normal 24 hr.

100 mg/kg: Mod. to severe wk., diarrhea 2-4 hr.

200-800 mg/kg: Tremors, convulsions, diarrhea and death <24 hr.

2.5-24 hr

7+

 

*R= Rat

**PO= Orally

***NRC= No range calculable

Remarks: Moderately toxic to rats orally and highly toxic to mice orally.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
The LD50 was considered to be approximately 118 mg/kg with confidential limit of 84-167mg/kg bw, when rats were treated with Methyltriphenylphosphonium bromide (CAS no: 1779-49-3) via oral route.
Executive summary:

The acute oral toxicity of Methyltriphenylphosphonium bromide (CAS no: 1779-49-3) was tested in 20 rats at the dose concentration range of 50-800 mg/kg bw. The test substance was dissolved as 10% in water (Vehicle). Animals were observed for mortality, clinical signs and body weight change for 14 days. 50% mortality was observed within 2.5-24 hr at 118 mg/kg bw. Clinical signs were observed in treated rats. At 50 mg/kg symptoms like diarrhea was observed in 2-4 hr. which was normal within 24 hr, considered to be slightly to moderate; At 100 mg/kg symptoms like diarrhea was observed in 2-4 hr which was considered as moderate to severe; and At the range of 200-800 mg/kg: Tremors, convulsions, diarrhea and death within 24 hr was observed which was considered to be highly toxic. Weight change was observed in more than 7 rats. Therefore, LD50 was considered to be approximately 118 mg/kg with confidential limit of 84-167mg/kg bw, when rats were treated with Methyltriphenylphosphonium bromide via oral route.