Registration Dossier

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Bis(2-ethylhexyl)zinkdithiophosphat [MAK Value Documentation in German language, 2004]
Author:
The MAK Collection for Occupational Health and Safety
Year:
2012
Bibliographic source:
Bis(2-ethylhexyl)zinkdithiophosphat [MAK Value Documentation in German language, 2004]. The MAK Collection for Occupational Health and Safety. 1–14. 2012.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
To assess the ocular irritation potential of chemical bis (2-ethylhexyl) zinc dithiophosphate (CAS No: 4259-15-8) in accordance with OECD Test Guideline 405.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
zinc bis[O,O–bis(2–ethylhexyl)] bis(dithiophosphate))
Cas Number:
4259-15-8
Molecular formula:
C16H35O2PS2.1/2Zn
IUPAC Name:
zinc bis[O,O–bis(2–ethylhexyl)] bis(dithiophosphate))
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report):zinc bis[O,O–bis(2–ethylhexyl)] bis(dithiophosphate))
- Molecular formula:C16H35O2PS2.1/2Zn
- Molecular weight :772.487 g/mole
- Substance type:Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):zinc bis[O,O–bis(2–ethylhexyl)] bis(dithiophosphate))
- Molecular formula:C16H35O2PS2.1/2Zn
- Molecular weight :772.487 g/mole
- Substance type:Organic

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
100%
Duration of treatment / exposure:
Single exposure
Observation period (in vivo):
96 hours
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
other:
Basis:
mean
Time point:
other: 96 h
Score:
23.5
Max. score:
110
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Eye irritation was observed in treated rabbits

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
The mean Primary irritation index scores after 96 hour was 23.5 out of maximum score of 110. Hence, bis (2-ethylhexyl) zinc dithiophosphate (CAS No: 4259-15-8) can be considered to be irritating to rabbit eyes.
Executive summary:

An eye irritation study was carried out on rabbits to assess the eye irritation potential of chemical thebis (2-ethylhexyl) zinc dithiophosphate (CAS No: 4259-15-8) in accordance with OECD Test Guideline 405.

 

During this test, theundiluted test chemicalwas instilled into eyes of each rabbits. The rabbits were observed and scored for signs of irritation at 96 hours.

 

The meanPrimary irritation indexscores after 96 hour was 23.5 out of maximum score of 110.Hence,bis (2-ethylhexyl) zinc dithiophosphate (CAS No: 4259-15-8)can be considered to irritating to rabbit eyes.