3-methylbutyl butyrate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014-12-01 to 2014-12-05

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

(1995)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Principles of method if other than guideline:

Analytical quantification of the test item was carried out via HPLC with DAD on a reversed phase analytical column.

GLP compliance:

yes (incl. QA statement)

Remarks:

issued 2013-11-13

Type of method:

flask method

Key result

Water solubility:

184.7 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

1.1 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

5.8

Details on results:

Preliminary Test (non-GLP): The determined solubility was in the range of 0.18 – 0.22 g/L.

Water Solubility Results at 20°C for the test item

Preincubation time	Replicate No.	Isoamyl butyrate [mg/L]
		Concentration^1	Mean
24 h	1	172.3	180.9
	2	189.4
48 h	1	186.4	188.7
	2	191.0
72 h	1	187.5	184.5
	2	181.6
Mean (24-72h)			184.7
Deviation [%] (24-72 h)			4.35

¹ Mean value of two injections

Check of temperature:

Temperature at incubation phase, 30°C and thermostatisation phase, 20°C (measured hourly)

Intended temperature [°C]	Measured temperature [°C]
	Min	Max	Mean value ± SD
30.0 ± 0.5	29.87	30.09	30.00 ± 0.04
20.0 ± 0.5	20.06	20.12	20.09 ± 0.01

pH-value of the Test Mixtures

Preincubation time	Replicate No.	Measured pH
24 h	1	6.336	5.8
	2	6.130
48 h	1	5.967
	2	5.478
72 h	1	5.398
	2	5.647

No tyndall effect was detected during the incubation time.

Validity criteria were fulfilled: The concentration measured did not differ more than 15%, temperatures were kept constant within±0.5°C.

Conclusions:

The water solubility of the test item was determined to be 184.7 mg/L (pH 5.8) at 20 +- 0.5°C.

Executive summary:

The test item has a water solubility of 184.7 mg/L (pH 5.8) at 20 +- 0.5°C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).

Description of key information

The water solubility is 184.7 mg/L (pH 5.8) at 20±0.5°C.

Key value for chemical safety assessment

Water solubility:

184.7 mg/L

at the temperature of:

20 °C

Additional information

The test item has a water solubility of 184.7 mg/L (pH 5.8) at 20 +- 0.5°C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).