Registration Dossier
Registration Dossier
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EC number: 911-358-0 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Environment and Quality of Life - Reports (Seventh Series)
- Author:
- European Commission (EC) - Scientific Committee on Cosmetology (SCC)
- Year:
- 1 987
- Bibliographic source:
- Environment and Quality of Life - Reports (Seventh Series), European Commission (EC) - Scientific Committee on Cosmetology (SCC),1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1,4-bis(butylamino)anthraquinone
- EC Number:
- 241-379-4
- EC Name:
- 1,4-bis(butylamino)anthraquinone
- Cas Number:
- 17354-14-2
- Molecular formula:
- C22H26N2O2
- IUPAC Name:
- 1,4-bis(butylamino)-9,10-anthraquinone
- Details on test material:
- Name: 1,4-bis(butylamino)-9,10-anthraquinone
InChI: 1S/C22H26N2O2/c1-3-5-13-23-17-11-12-18(24-14-6-4-2)20-19(17)21(25)15-9-7-8-10-16(15)22(20)26/h7-12,23-24H,3-6,13-14H2,1-2H3
Smiles: CCCCNc1ccc(NCCCC)c2C(=O) c3ccccc3C(=O)c12
Name of test material :Solvent Blue 35
Molecular formula :C22H26N2O2
Molecular weight :350.4594 g/mol
Substance type:Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 4350 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 350 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be 4350 mg/kg bw, when rats were treated with test chemical via oral route.
- Executive summary:
Acute oral toxicity study of test chemical was conducted in rat at the concentration of 4350 mg/kg bw. 50% mortality was observed at 5000 mg/kg bw. Therefore,LD50 was considered to be 4350 mg/kg bw, when rats were treated with test chemical via oral route.
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