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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source.

Data source

Reference
Reference Type:
secondary source
Title:
Environment and Quality of Life - Reports (Seventh Series)
Author:
European Commission (EC) - Scientific Committee on Cosmetology (SCC)
Year:
1987
Bibliographic source:
Environment and Quality of Life - Reports (Seventh Series), European Commission (EC) - Scientific Committee on Cosmetology (SCC),1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of test chemical in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-bis(butylamino)anthraquinone
EC Number:
241-379-4
EC Name:
1,4-bis(butylamino)anthraquinone
Cas Number:
17354-14-2
Molecular formula:
C22H26N2O2
IUPAC Name:
1,4-bis(butylamino)-9,10-anthraquinone
Details on test material:
Name: 1,4-bis(butylamino)-9,10-anthraquinone
InChI: 1S/C22H26N2O2/c1-3-5-13-23-17-11-12-18(24-14-6-4-2)20-19(17)21(25)15-9-7-8-10-16(15)22(20)26/h7-12,23-24H,3-6,13-14H2,1-2H3
Smiles: CCCCNc1ccc(NCCCC)c2C(=O) c3ccccc3C(=O)c12
Name of test material :Solvent Blue 35
Molecular formula :C22H26N2O2
Molecular weight :350.4594 g/mol
Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
4350 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 350 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be 4350 mg/kg bw, when rats were treated with test chemical via oral route.
Executive summary:

Acute oral toxicity study of test chemical was conducted in rat at the concentration of 4350 mg/kg bw. 50% mortality was observed at 5000 mg/kg bw. Therefore,LD50 was considered to be 4350 mg/kg bw, when rats were treated with test chemical via oral route.

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