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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

As there is no experimental data the bioaccumulation behaviour of this substance was assessed using QSAR estimations of reaction educts as well as reaction products.

Both give that the BCF can be expected in the range of 3.16 - 379.

According to the decision of ECHA number: SEV-D-2114405647 -48 -01/F a dietary exposure bioaccumulation study in fish according OECD 305 was commissioned to IBACON ( Ibacon Project 136871233). Due to the complex composition of the test item and the lack of analytical and extraction methods there is a need for comprehensive analytical method development which lead to a delay of receiving the results of that study until estimated by Ibacon March 2020 ( see attachment). We have already informed the eMS about this delay and ECHA ( INC000000261807). In following the recommendation we put this information into the endpoint summary of BIoaccumulation: aquatic/sediment. After receiving the results this endpoint will be updated accordingly and the updated dossier will be submitted to ECHA.

Key value for chemical safety assessment

BCF (aquatic species):
379 dimensionless

Additional information

There is no experimental study on bioaccumulation behaviour of this UVCB substance. Therefore, bioaccumulation was evaluated based on QSAR estimation of reaction educts (propylene oxyde, n-butyl-glycidyl ether) and an experimental study of tetrabrom-bisphenol A, as well as with reaction products (smallest and largest reaction product molecule).

 ---Educts: QSAR estimation showed negligible bioaccumulation potential BCF = 3.16 for propylene oxyde, n-butyl-glycidyl ether and a low experimental BCF <= 170 for tetrabrom-bisphenol A .

--- Products: The smallest and the largest reaction product molecule were used for QSAR estimation and showed a low BCF = 379.

QSAR estimations and the experimental study are assumed to be appropriate for risk assessment as well as classification purposes. The highest BCF = 379 was taken forward to the risk assessment. Based on this highest BCF the substance does clearly not fulfill the B and vB criterion of the PBT assessment, in particular, as the substance also does not fulfill the T criterion. It is very unlikely that an experimental study would provide relevant new information that is significantly different from the result described above and that risk assessment or classification would have to be updated. Therefore, and in order to avoid unnecessary animal testing a study on the bioaccumulation behavior of the substance is not justified and no study proposal is submitted. The available data are sufficient for assessment.