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Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The data obtained from a source of secondary literature are related to a substance which shows the same functional groups . The data derived from read-across is considered reliable because the molecules have the same functional groups due to the action irritating.
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
no
Species:
rabbit
Strain:
not specified
Type of coverage:
not specified
Controls:
not specified
Irritation parameter:
other: REACTION: Severe
Irritant / corrosive response data:
REACTION: Severe
Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008, the substance is classified for this property.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008, the substance is classified as irritant.


Justification for selection of skin irritation / corrosion endpoint:
The data obtained from a source of secondary literature are related to a substance which shows the same functional groups . The data derived from read-across is considered reliable because the molecules have the same functional groups due to the action irritating.

Effects on skin irritation/corrosion: irritating

Justification for classification or non-classification

According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008, the substance is classified as irritant.

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