Registration Dossier
Registration Dossier
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EC number: 283-640-5 | CAS number: 84696-21-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Hydrocotyle asiatica, Umbelliferae.
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- -0.333
- Temp.:
- 30 °C
- Remarks on result:
- other: pH not available
- Conclusions:
- The estimated partition coefficient result
Pow = 0.46 Log Pow = -0.333
Reference
| Sample Name | *Dried sample weight [g] | Vol. of water added [mL] | Dried residue weight [g] | Solubilized test item weight [g] | n-octanol solubility [g/L] |
| 1 | 3.2839 | 40 | 2.9456 | 0.3383 | 8.46 |
| 2 | 2.9359 | 40 | 2.5905 | 0.3454 | 8.64 |
| 3 | 1.2523 | 10 | 1.1542 | 0.0981 | 9.81 |
| 4 | 1.4824 | 10 | 1.3858 | 0.0966 | 9.66 |
| MEAN | 9.14 |
* The water content (2.6 % w/w), for the calculation as dried sample, was determined following the CIPAC method MT 17.4. The sample was heated at 90°C until constant weight was reached.
The repeated 4 trial match the required reproducibility (<15%) then the mean value was adopted. The n-octanol solubility of Centella Asiatica Dried Extract resulted 9.14 g/L.
Pow estimated = Solubility of test item in n-octanol / Solubility of test item in water = 9.14 / 19.68 = 0.46
Description of key information
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.333
Additional information
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