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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
-0.333
Temp.:
30 °C
Remarks on result:
other: pH not available
Sample Name *Dried sample weight [g]   Vol. of water added [mL]  Dried residue weight [g]  Solubilized test item weight [g] n-octanol solubility [g/L] 
 1  3.2839  40  2.9456  0.3383  8.46
 2  2.9359  40  2.5905  0.3454  8.64
 3  1.2523  10  1.1542  0.0981  9.81
 4  1.4824  10  1.3858 0.0966   9.66
         MEAN  9.14

* The water content (2.6 % w/w), for the calculation as dried sample, was determined following the CIPAC method MT 17.4. The sample was heated at 90°C until constant weight was reached.

The repeated 4 trial match the required reproducibility (<15%) then the mean value was adopted. The n-octanol solubility of Centella Asiatica Dried Extract resulted 9.14 g/L.

Pow estimated = Solubility of test item in n-octanol / Solubility of test item in water = 9.14 / 19.68 = 0.46

Conclusions:
The estimated partition coefficient result
Pow = 0.46 Log Pow = -0.333

Description of key information

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.333

Additional information