Registration Dossier
Registration Dossier
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EC number: 283-640-5 | CAS number: 84696-21-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Hydrocotyle asiatica, Umbelliferae.
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
- Water solubility:
- 19.68 g/L
- Conc. based on:
- test mat.
- Temp.:
- 90 °C
- Remarks on result:
- other: pH not available
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of Centella Asiatica dried extract resulted 19.68 g/L
Reference
(*) The water content (2.6% w/w), for the calculation as dried sample, was determined following the CIPAC method MT 17.4. The sample was heated at 90°C until weight was reached. The repeated 5 test match the required reproducibility (<15%), then the mean value was adopted.
| Sample name | Dried* sample weight (g) | Vol. of water added (mL) | Dried residue weight (g) | Solubilized test item weight (g) | Water solubility (g/L) |
| 1 | 0.9550 | 40 | 0.2835 | 0.6715 | 16.79 |
| 2 | 2.0151 | 40 | 1.2397 | 0.7754 | 19.38 |
| 3 | 3.1803 | 40 | 2.3323 | 0.8480 | 21.20 |
| 4 | 3.0859 | 40 | 2.3120 | 0.7739 | 19.35 |
| 5 | 0.9460 | 20 | 0.5119 | 0.4341 | 21.70 |
| MEAN | 19.68 |
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 19.68 g/L
- at the temperature of:
- 90 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
