Registration Dossier
Registration Dossier
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EC number: 617-813-7 | CAS number: 861960-34-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BONIFACE M. et B., CAZIN J.C et LUYCKX J. Calcul, sur ordinateur, de la dose efficace par la méthode des probits : Application au calcul d’une dose létale 50. Bull Soc. Pharm. Lille, 1972, 4, 187-185
CAZIN J.L. Exemples d’utilisation de micro-ordinateurs en génie biologique et médical (Apple II et III) Diplôme d’Etudes Approfondies de Génie Biologique et Médical. 1983, Faculté de Pharmacie de Lille.
BLISS C.I. The determination of the dosage-mortalité curve from small numbers. Quart J. Pharm., 1938, 11, 1926. - GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- (7-Methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile
- EC Number:
- 617-813-7
- Cas Number:
- 861960-34-1
- Molecular formula:
- C13H13NO
- IUPAC Name:
- (7-Methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: gommi arabicum
- Doses:
- 5%
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat. (dissolved fraction)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the experimental conditions, the oral LD50 of the test item Hydrocyan is higher than 5000 mg/kg in rats
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