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EC number: 916-898-0
CAS number: -
The test with the strain TA-1537 was
repeated because the activation system was not added to the positive
control plates during the first trial. The repeat test was also negative.
The test item was evaluated for its
potential to induce mutagenic effects in an in vitro bacterial
inverse mutation assay (Ames test), according to a method similar to the
OECD 471 guideline. Salmonella typhimurium strains TA 1535, TA
1537, TA 1538, TA 98 and TA 100 were exposed to test item concentrations
ranging from 1.0 to 10,000 µg/plate both in the presence and absence of
S9 metabolic activation. The test item showed no toxicity to the TA-100
indicator strain during a preliminary test, which determined the
appropriate test item concentrations.
The test item showed no genetic
activity in any of the concentrations or replicates conducted, with or
without metabolic activation. Therefore, the test item can be considered
non-mutagenic in these test conditions. The higher concentrations used
counterbalance the shortcomings that could result from the use of a test
item with a low purity used suggest that the use of the experimental
results for the evaluation of mutagenicity is acceptable.
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