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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VIII
Author:
Carpenter, CP, Weil, CS and Smyth, HF
Year:
1974
Bibliographic source:
Toxicology and Applied Pharmacology 28, 313-319

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Not specified
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenylethanol
EC Number:
200-456-2
EC Name:
2-phenylethanol
Cas Number:
60-12-8
Molecular formula:
C8H10O
IUPAC Name:
2-phenylethanol
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2.46 mL/kg bw
Based on:
test mat.
95% CL:
>= 1.79 - <= 3.39
Remarks on result:
other: Equivalent to 2510 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 is 2510 mg/kg bw.
Executive summary:

The acute oral LD50 of 2 -phenylethanol is 2.46 mL/kg bw which is equivalent to 2510 mg/kg bw based on a density of 1.0202 g/cm3.