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EC number: 276-115-7
CAS number: 71873-39-7
INDIVIDUAL DERMAL REACTIONS
STA: pink-coloured staining
Cf: crust formation
The study was performed to assess the
irritancy potential of the test material to the skin of the New Zealand
White rabbit. The method used that described in the OECD Guidelines 404.
A single 4-hour, semi-occluded application of the test material to the
intact skin of three rabbits produced very slight to well-defined
erythema and very slight to slight oedema. Skin reactions noted at all
treated skin sites seven days after treatment were crust formation and
The test material produced a primary
irritation index of 1.7 and was classified as a mild irritant to rabbit
skin, according to the Draize classification scheme. No corrosive
effects were noted.
The mean values from gradings at 24, 48
and 72 hours after patch removal were lower than 2.3 in all animals for
both erythema/eschar and oedema reactions, thus the test item does not
meet the criteria to be classified as irritating, according to the CLP
(EC 1272/2008) Regulation.
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