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Diss Factsheets

Administrative data

Endpoint:
thermal stability
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
11 January 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)
Version / remarks:
1981
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Adenosine 5'-(tetrahydrogen triphosphate), disodium salt
EC Number:
213-579-1
EC Name:
Adenosine 5'-(tetrahydrogen triphosphate), disodium salt
Cas Number:
987-65-5
Molecular formula:
C10H14N5O13P3.2Na
IUPAC Name:
disodium hydrogen [({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphonato)oxy]phosphonate
impurity 1
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
Oxidane
impurity 2
Reference substance name:
Unknown impurities.
Molecular formula:
Not available as unknown impurities.
IUPAC Name:
Unknown impurities.
Test material form:
solid: crystalline
Details on test material:
Storage conditions: 2-8°C
Batch No: 11678500

Results and discussion

For thermal stability study

Test substance thermally stable:
no
Remarks:
First endothermic effect was observed in the temperature range of 110 °C – 135 °C directly followed by an exothermic effect in the temperature range of 135 – 190 °. A second exothermic effect was detected in the temperature range of 200 – 290 °C.
Operating temperatureopen allclose all
Key result
Operating temp.:
> 110 - < 135 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
> 135 - < 190 °C
Remarks on result:
other: exothermic effect
Key result
Operating temp.:
> 200 - < 290 °C
Remarks on result:
other: exothermic effect
Sublimation:
not determined
Transformation products:
not specified

Any other information on results incl. tables

In the temperature range of 110 °C – 135 °C, an endothermic effect was observed, which was directly followed by an exothermic effect in the temperature range of 135 – 190 °C, with a decomposition energy of -190 J/g. A second exothermic effect was detected in the temperature range of 200 – 290 °C, with a decomposition energy of -80 J/g. The test was terminated at 300 °C.

Applicant's summary and conclusion

Conclusions:
In the DSC-measurements the test item ATP, Di-Na (CAS 987-65-5) showed an endothermic effect in the temperature range of 110 °C – 135 °C, which was directly followed by an exothermic effect in the temperature range of 135 – 190 °C, with a decomposition energy of -190 J/g. A second exothermic effect was detected in the temperature range of 200 – 290 °C, with a decomposition energy of -80 J/g.
Executive summary:

In the DSC-measurements the test item ATP, Di-Na (CAS 987-65-5) showed an endothermic effect in the temperature range of 110 °C – 135 °C, which was directly followed by an exothermic effect in the temperature range of 135 – 190 °C, with a decomposition energy of -190 J/g. A second exothermic effect was detected in the temperature range of 200 – 290 °C, with a decomposition energy of -80 J/g. The test was terminated at 300 °C.