Registration Dossier
Registration Dossier
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EC number: 263-760-4 | CAS number: 62924-31-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- (E)-(4-methoxy-2,3,6-trimethylphenyl)-3-buten-2-one
- EC Number:
- 263-760-4
- EC Name:
- (E)-(4-methoxy-2,3,6-trimethylphenyl)-3-buten-2-one
- Cas Number:
- 62924-31-6
- Molecular formula:
- C14H18O2
- IUPAC Name:
- 1-(4-methoxy-2,3,6-trimethylphenyl)but-3-en-2-one
- Test material form:
- solid: particulate/powder
1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality.
- Clinical signs:
- other: A decrease in spontaneous activity and myosis were noted during the first hours of the test. The animals recovered a normal behaviour between 4 and 24 hrs post-dose.
- Gross pathology:
- No treatment related changes.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the test item is higher than 2000 mg/kg bw by oral route in the rat.
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