Registration Dossier
Registration Dossier
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EC number: 298-995-1 | CAS number: 93841-25-9
Endpoint summary
Administrative data
Description of key information
In a repeated open-epicutaneous application to the albino guinea pig following the method according to Draize no indication of a skin irritating potential of 1-beta-hydroxyethyl-2,5-diaminobenzene dihydrochloride tested at a 3% aqueous solution in a repeated application assay in Guinea pigs was noted. The substance 2-(2,5 -diaminophenyl)ethanol sulfate (1:1) is assigned a skin irritation classification as a precautionary measure.
Under the conditions of the test performed according to OECD guideline 405, undiluted 2-(2,5-diaminophenyl)ethanol sulfate (Betoxol) was irritant to the rabbit eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
In a repeated open-epicutaneous application to the albino guinea pig following the method according to Draize no indication of a skin irritating potential of 1-beta-hydroxyethyl-2,5-diaminobenzene dihydrochloride tested at a 3% aqueous solution in a repeated application assay in Guinea pigs was noted. The substance 2-(2,5 -diaminophenyl)ethanol sulfate (1:1) is assigned a skin irritation classification as a precautionary measure.
Under the conditions of the test performed according to OECD guideline 405, undiluted 2-(2,5-diaminophenyl)ethanol sulfate (Betoxol) was irritant to the rabbit eye.
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