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Description of key information

In a repeated open-epicutaneous application to the albino guinea pig following the method according to Draize no indication of a skin irritating potential of 1-beta-hydroxyethyl-2,5-diaminobenzene dihydrochloride tested at a 3% aqueous solution in a repeated application assay in Guinea pigs was noted. The substance 2-(2,5 -diaminophenyl)ethanol sulfate (1:1) is assigned a skin irritation classification as a precautionary measure.

Under the conditions of the test performed according to OECD guideline 405, undiluted 2-(2,5-diaminophenyl)ethanol sulfate (Betoxol) was irritant to the rabbit eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

In a repeated open-epicutaneous application to the albino guinea pig following the method according to Draize no indication of a skin irritating potential of 1-beta-hydroxyethyl-2,5-diaminobenzene dihydrochloride tested at a 3% aqueous solution in a repeated application assay in Guinea pigs was noted. The substance 2-(2,5 -diaminophenyl)ethanol sulfate (1:1) is assigned a skin irritation classification as a precautionary measure.

Under the conditions of the test performed according to OECD guideline 405, undiluted 2-(2,5-diaminophenyl)ethanol sulfate (Betoxol) was irritant to the rabbit eye.

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