Registration Dossier
Registration Dossier
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EC number: 607-858-0 | CAS number: 260781-16-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-03-14 to 1994-06-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 1994-03-16
- Type of method:
- flask method
- Key result
- Water solubility:
- 88.8 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 48 - <= 96 h
- Temp.:
- 20 °C
- pH:
- >= 6.9 - <= 7
- Remarks on result:
- other: loading of aqueous phase: ~ 0.75 g/L
- Conclusions:
- According to Council Directive 92/69/EEC A.6, the water solubility of the test item is 88.8 mg/L (20 °C ± 0.5 °C, pH 6.9). The test substance is slightly soluble.
Reference
RESULTS
The preliminary test determined the water solubility to be less than 0.10 g/L. The mean peak heights relating to the standard and sample solutions are detailed below:
| Solution | Mean peak height |
| Standard 501 mg/L | 1.406 x 105 |
| Standard 520 mg/L | 1.470 x 105 |
| Sample 1 | 1.387 x 105 |
| Sample 2 | 1.141 x 105 |
| Sample 3 | 1.225 x 105 |
| Sample number | Time shaken at 30 °C [h] | Time held at 20 °C [h] | Concentration [g/L] | Solution pH |
| 1 | 24 | 24 | 9.84 x 10-2 | 6.9 |
| 2 | 48 | 24 | 8.10 x 10-2 | 6.9 |
| 3 | 72 | 24 | 8.69 x 10-2 | 7.0 |
Mean = 8.88 x 10-2 g/L
Range = 8.10 x 10-2 to 9.84 x 10-2 g/L
Description of key information
The water solubility of the test substance is 88.8 mg/L (20 °C ± 0.5 °C, pH 6.9).
Key value for chemical safety assessment
- Water solubility:
- 88.8 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the substance was performed in accordance to Council Directive 92/69/EEC A.6 under GLP. Based on preliminary results the flask method was applied. The substance was analytically verified using GC.
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