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Diss Factsheets

Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 29 February 2016 to October 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Key result
Water solubility:
< 0.01 g/L
Conc. based on:
test mat.
Temp.:
19 °C
Remarks on result:
other: result of the preliminary test based on visual observation
Key result
Water solubility:
3.2 mg/L
Conc. based on:
other: expressed in Lutetium
Remarks:
corresponds to a concentration of 6.6 mg/l in active ingredient
Temp.:
20 °C
pH:
5.8
Remarks on result:
other: flow rate of 25 ml/hour
Key result
Water solubility:
2.7 mg/L
Conc. based on:
other: expressed as Lutetium
Remarks:
corresponds to a concentration of 5.6 mg/l in active ingredient
Temp.:
20 °C
pH:
5.8
Remarks on result:
other: flow rate of 25 ml/hour
Key result
Water solubility:
3.1 mg/L
Conc. based on:
other: expressed as lutetium
Remarks:
corresponds to a concentration of 6.4 mg/l in active ingredient
Temp.:
20 °C
pH:
5.9
Remarks on result:
other: flow rate of 12.5 ml/hour
Key result
Water solubility:
3 mg/L
Conc. based on:
other: expressed as Lutetium
Remarks:
corresponds to a concentration of 6.2 mg/l in active ingredient
Temp.:
20 °C
pH:
5.8
Remarks on result:
other: mean of water solubility measured in three vessels
Conclusions:
The mean water solubility of the test item at 20°C is 3.0 mg/l expressed as Lutetium content. This value corresponds to a concentration of 6.2 mg/l expressed in active ingredient.
Under the conditions of the test the pH was of 5.8.
Executive summary:

The water solubility was determined with the column elution method according to recognized guidelines (EU method A.6 and OECD guideline 105) and under GLP. No deviation from the guidelines was observed during the test.

The analytical method used to quantify the test item in the test samples was validated before the performance of the test.

The water solubility of the test item at 20°C is 3.0 mg/l expressed as Lutetium content. This value corresponds to a concentration of 6.2 mg/l expressed in active ingredient. Under the conditions of the test the pH was of 5.8.

Description of key information

The water solubility was determined with the column elution method according to recognized guidelines (EU method A.6 and OECD guideline 105) and under GLP. No deviation from the guidelines was observed during the test.

The analytical method used to quantify the test item in the test samples was validated before the performance of the test.

The water solubility of the test item at 20°C is 3.0 mg/l expressed as Lutetium content. This value corresponds to a concentration of 6.2 mg/l expressed in active ingredient under the conditions of the test the pH was of 5.8.

Key value for chemical safety assessment

Water solubility:
6.2 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test item at 20°C is 3.0 mg/l expressed as Lutetium content. This value corresponds to a concentration of 6.2 mg/l expressed in active ingredient under the conditions of the test the pH was of 5.8.