Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16-29 November 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
GLP compliance:
yes
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenylimidazole
EC Number:
211-581-7
EC Name:
2-phenylimidazole
Cas Number:
670-96-2
Molecular formula:
C9H8N2
IUPAC Name:
2-phenyl-1H-imidazole
Test material form:
solid: flakes

Results and discussion

Water solubility
Key result
Water solubility:
1.86 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
>= 9.57 - <= 9.66

Any other information on results incl. tables

Preliminary test of water solubility

The aqueous solubility at 25°C of the test itemwas reported below.

Global results of the preliminary test of water solubility at 25°C.

 

Preliminary test

Approximate solubility ~ 0.7g/L

pH of watery solution

9.51

 

Water solubility tests

The aqueous solubility at 20°C of the test item is reported below:

Water solubility test

Aqueous solubility 1.86 g/L

RSD% = 1.12%

The results from vessels 1 and 2 shown a tendency of increasing values while rest constant from vessel 2 to vessel 5; For this reason the results of these three last flasks, which did not differ by more than 15%, are averaged. The vessel 5 was not considered: it was injected after 5 days and 1/2 at 30°C, without conditionning at 20° C for 24 hours.

The whole test (with longer equilibration times, see values of vessels from 1 to 4) was reported too.

pH determinations

The pH determination at 20°C of each test sample is reported below:

pH

S1

S2

S3

S4

S5

pH (20°C)

9.66

9.57

9.64

9.62

9.53

Conclusions

The water solubility of test item at 20° C proved to be 1.86 g/L

Applicant's summary and conclusion