Registration Dossier
Registration Dossier
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EC number: 241-143-0 | CAS number: 17084-13-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- unknown
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Fluorine Chemistry Volume 4
- Author:
- Simons JH
- Year:
- 1 965
- Bibliographic source:
- ISBN: 978-0-12-395577-7. Pages 37-42.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Original publication not available. The study was conducted before 1965.
- GLP compliance:
- no
- Test type:
- other: not specified; original publication not available.
Test material
- Reference substance name:
- Potassium hexafluorophosphate
- EC Number:
- 241-143-0
- EC Name:
- Potassium hexafluorophosphate
- Cas Number:
- 17084-13-8
- Molecular formula:
- F6P.K
- IUPAC Name:
- potassium hexafluoro-λ⁵-phosphanuide
Constituent 1
- Specific details on test material used for the study:
- no specific details provided.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 270 days
- Weight at study initiation: 319 - 397 g
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- original publication not available
- Doses:
- Not specified. Original publication not available
- No. of animals per sex per dose:
- Not specified. In total, 29 animals were tested.
- Control animals:
- not specified
- Details on study design:
- original publication not available
Results and discussion
- Preliminary study:
- not described
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- original publication not available
- Clinical signs:
- other: original publication not available
- Gross pathology:
- original publication not available
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral toxicity (LD50) of the test item was determined to be in the range of 1400 ± 78 mg/kg bw in male rats.
- Executive summary:
In an acute oral toxicity study published in the handbook “Fluorine Chemistry IV”, male rats were given a single oral dose of potassium hexafluorophosphate and observed for 24 h.
Oral LD50 Males = 1400 ± 78 mg/kg bw
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