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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1975
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: A scientific review (peer reviewed). No data on test method. No data on GLP.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
2008
Reference Type:
publication
Title:
Unnamed
Year:
1976

Materials and methods

Principles of method if other than guideline:
- Principle of test: Skin absorption of fenchyl acetate was assessed in 5 male mice.
- Short description of test conditions: An area of 2.2 cm2 on the shaved abdominal skin was used. Eserine (0.23%) was used as an indicator and the test material was used as a carrier for eserine.
- Parameters analysed / observed: The latency period between application to the skin and the appearance of the eserine effect in the periodically stimulated masticatory muscles was used as a measure of the absorption rate.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3-dimethyl-8,9-dinorbornan-2-yl acetate
EC Number:
237-588-5
EC Name:
3,3-dimethyl-8,9-dinorbornan-2-yl acetate
Cas Number:
13851-11-1
Molecular formula:
C12H20O2
IUPAC Name:
1,3,3-trimethylbicyclo[2.2.1]hept-2-yl acetate
Radiolabelling:
not specified

Test animals

Species:
mouse
Strain:
not specified
Sex:
male

Administration / exposure

No. of animals per group:
5
Details on study design:
An area of 2.2 cm2 on the shaved abdominal skin was used. Eserine (0.23%) was used as an indicator and the test material was used as a carrier for eserine. The latency period between application to the skin and the appearance of the eserine effect in the periodically stimulated masticatory muscles was used as a measure of the absorption rate.

Results and discussion

Any other information on results incl. tables

Dermal absorption of fenchyl acetate was moderately slow (54 min) in mice.

Applicant's summary and conclusion

Conclusions:
Dermal absorption of fenchyl acetate was moderately slow (54 min) in mice.
Executive summary:

Skin absorption of fenchyl acetate was assessed in 5 male mice. An area of 2.2 cm2 on the shaved abdominal skin was used. Eserine (0.23%) was used as an indicator and the test material was used as a carrier for eserine. The latency period between application to the skin and the appearance of the eserine effect in the periodically stimulated masticatory muscles was used as a measure of the absorption rate. Dermal absorption of fenchyl acetate was moderately slow (54 min) in mice.