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Description of key information

Acute oral toxicity: supporting study: The acute oral LD50 value of the test substance is greater than 5000 mg/kg bw in rats.

Acute dermal toxicity: supporting study: The acute dermal LD50 value of the test substance was greater than 5000 mg/kg bw in rabbits.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
A scientific review (peer reviewed). No data on GLP.
Principles of method if other than guideline:
-principle of test: Ten rats received single oral doses of 5.0 g/kg test material each. Animals were observed for 14 days. No details on the method.
Test type:
acute toxic class method
Species:
rat
Sex:
not specified
Route of administration:
oral: unspecified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10 animals
Control animals:
not specified
Details on study design:
Animals were observed for 14 days
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
Two animals died (2/10).
Clinical signs:
No adverse clinical signs were observed
Interpretation of results:
other: Not classified (CLP Regulation EC no. 1272/2008)
Conclusions:
Oral LD50 (rats) is greater than 5000 mg/kg bw.
Executive summary:

The acute oral LD50 of fenchyl acetate was reported to exceed 5000 mg/kg bw. Ten rats received single oral doses of 5.0 g/kg test material each. Animals were observed for 14 days. Two animals died (2/10). No adverse clinical signs were observed.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw
Quality of whole database:
supporting study with Klimisch score = 2

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1975
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: A scientific review (peer reviewed). No data on GLP. Evaluated during a skin absorption study.
Principles of method if other than guideline:
-Principle of test: Acute dermal toxicity was evaluated during a skin absorption study. Two mice were each administered a single 4-hour dermal application of neat fenchyl acetate on the shaved abdominal skin. Observations were made after 4 hours.
GLP compliance:
no
Test type:
other: no data
Species:
rabbit
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No (0/10) deaths were observed.
Clinical signs:
No clinical signs were observed
Interpretation of results:
other: Not classified (CLP Regulation EC no. 1272/2008)
Conclusions:
The dermal LD50 in rabbit is greater than 5000 mg/kg bw
Executive summary:

The acute dermal LD50 for fenchyl acetate in rabbits exceeded 5000 mg/kg based on no (0/10) deaths at that dose. Ten rabbits each received a single dermal application of neat test material. Animals were observed for 14 days. No clinical signs were observed.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw
Quality of whole database:
supporting study with Klimisch score = 3

Additional information

Acute oral toxicity: supporting study: The acute oral LD50 of fenchyl acetate was reported to exceed 5000 mg/kg bw. Ten rats received single oral doses of 5.0 g/kg test material each. Animals were observed for 14 days. Two animals died (2/10). No adverse clinical signs were observed.

Acute dermal toxicity: supporting study: The acute dermal LD50 for fenchyl acetate in rabbits exceeded 5000 mg/kg based on no (0/10) deaths at that dose. Ten rabbits each received a single dermal application of neat test material. Animals were observed for 14 days. No clinical signs were observed.

Justification for classification or non-classification

The substance is classified as Aspiration Toxicity Category 1, H304 in accordance with CLP Regulation (EC) no. 1272/2008 since it is a hydrocarbon and has a kinematic viscosity less than 20,5 mm2/s at 40 ºC.