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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
A scientific review (peer reviewed). No data on GLP.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
2008
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1976

Materials and methods

Principles of method if other than guideline:
-principle of test: Ten rats received single oral doses of 5.0 g/kg test material each. Animals were observed for 14 days. No details on the method.
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3-dimethyl-8,9-dinorbornan-2-yl acetate
EC Number:
237-588-5
EC Name:
3,3-dimethyl-8,9-dinorbornan-2-yl acetate
Cas Number:
13851-11-1
Molecular formula:
C12H20O2
IUPAC Name:
1,3,3-trimethylbicyclo[2.2.1]hept-2-yl acetate

Test animals

Species:
rat
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10 animals
Control animals:
not specified
Details on study design:
Animals were observed for 14 days

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
Two animals died (2/10).
Clinical signs:
No adverse clinical signs were observed

Applicant's summary and conclusion

Interpretation of results:
other: Not classified (CLP Regulation EC no. 1272/2008)
Conclusions:
Oral LD50 (rats) is greater than 5000 mg/kg bw.
Executive summary:

The acute oral LD50 of fenchyl acetate was reported to exceed 5000 mg/kg bw. Ten rats received single oral doses of 5.0 g/kg test material each. Animals were observed for 14 days. Two animals died (2/10). No adverse clinical signs were observed.

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