2-[bis(2-ethylhexyl)amino]ethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

disregarded due to major methodological deficiencies

Study period:

1953

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1953

Report date:

1953

Materials and methods

Principles of method if other than guideline:

Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-[bis(2-ethylhexyl)amino]ethanol

EC Number:

202-912-6

EC Name:

2-[bis(2-ethylhexyl)amino]ethanol

Cas Number:

101-07-5

Molecular formula:

C18H39NO

IUPAC Name:

2-[bis(2-ethylhexyl)amino]ethan-1-ol

Specific details on test material used for the study:

A sample of di (2-ethylhexyl) ethanolamine (S-5223) was received from S. Charleston on 11-12-52 for toxicological assay.

Test animals

Species:

rat

Sex:

male

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

air

Details on inhalation exposure:

Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

Substantially saturated vapor

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

Animals observed for 14 days.

Results and discussion

Mortality:

None.

Clinical signs:

other: Slight irritation of extremities.

Applicant's summary and conclusion

Conclusions:

Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical caused no mortality among 6 adult male rats exposed for 8 hours and observed subsequently for a total of 14 days. The only notable response was slight irritiation of extremities.

Executive summary:

Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical caused no mortality among 6 adult male rats exposed for 8 hours and observed subsequently for a total of 14 days. The only notable response was slight irritiation of extremities.