Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1953
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1953
Report date:
1953

Materials and methods

Principles of method if other than guideline:
Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[bis(2-ethylhexyl)amino]ethanol
EC Number:
202-912-6
EC Name:
2-[bis(2-ethylhexyl)amino]ethanol
Cas Number:
101-07-5
Molecular formula:
C18H39NO
IUPAC Name:
2-[bis(2-ethylhexyl)amino]ethan-1-ol
Specific details on test material used for the study:
A sample of di (2-ethylhexyl) ethanolamine (S-5223) was received from S. Charleston on 11-12-52 for toxicological assay.

Test animals

Species:
rat
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
Substantially saturated vapor
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
Animals observed for 14 days.

Results and discussion

Mortality:
None.
Clinical signs:
other: Slight irritation of extremities.

Applicant's summary and conclusion

Conclusions:
Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical caused no mortality among 6 adult male rats exposed for 8 hours and observed subsequently for a total of 14 days. The only notable response was slight irritiation of extremities.
Executive summary:

Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical caused no mortality among 6 adult male rats exposed for 8 hours and observed subsequently for a total of 14 days. The only notable response was slight irritiation of extremities.