(chloromethyl)vinylbenzene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1955

Report date:

1955

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Two rats per dose level were orally treated with different doses of the test substance vinylbenzyl chloride in corn oil.

GLP compliance:

no

Test type:

other: not specified, probably similar to standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

(chloromethyl)vinylbenzene

EC Number:

250-005-9

EC Name:

(chloromethyl)vinylbenzene

Cas Number:

30030-25-2

Molecular formula:

C9H9Cl

IUPAC Name:

1-(chloromethyl)-3-ethenylbenzene; 1-(chloromethyl)-4-ethenylbenzene

Test material form:

liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

corn oil

Remarks:

10 %

Doses:

0.126, 0.252, 0.5, 1.0 g/kg

No. of animals per sex per dose:

not specified

Control animals:

not specified

Statistics:

not reported

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 500 - < 1 000 mg/kg bw

Based on:

test mat.

Mortality:

Mortality occurred in 1 day after exposure to 1000 mg/kg bw (2 of 2 rats).

Any other information on results incl. tables

Animal	Preparation Fed	Dose (g/kg)	No died / No fed	Response-Remarks
Rat	10 % in corn oil	0.126	0/2	Slight irritation of the stomage. No other symptoms noted.
		0.252	0/2	Moderate irritation of the stomach and slight kidney pathology noted.
		0.5	0/2	Slight initial weight loss.
		1.0	2/2	Death occured in 1 day.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

This material vinylbenzyl chloride has a moderate acute oral toxicity. After oral uptake of 1 g of test substance per kg body weight (10 % in corn oil) death of the treated rat occured in one day.

Executive summary:

Two rats were treated with different doses of the test substance vinylbenzyl chloride in corn oil. At a concentration of 1 g/kg all test animals died after 1 day. At a dose of 0.5 g/kg only slight initial weight loss occured, at 0.252 g/kg moderate irritation of the stomach and slight kidney pathology was noted and at a dose of 0.126 g/kg slight irritation of the stomach and no other symptoms were noted.