(chloromethyl)vinylbenzene

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Title:

Unnamed

Year:

1970

Report date:

1970

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Groups of five rats, weighing 300 to 400 grams each, were exposed for 205 to 455 min to the vapors under dynamic conditions in a glass exposure jar.
During the exposures, the animals were observed for signs of irritation and respiratory distress. After the exposures, necropsies were done on the animals which succumbed. The survivors were kept for various observations for a 14-day period. Thereafter, the animals were sacrificed for gross pathological examinations.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

(chloromethyl)vinylbenzene

EC Number:

250-005-9

EC Name:

(chloromethyl)vinylbenzene

Cas Number:

30030-25-2

Molecular formula:

C9H9Cl

IUPAC Name:

1-(chloromethyl)-3-ethenylbenzene; 1-(chloromethyl)-4-ethenylbenzene

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

weighing 300 - 400 grams each

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

No. of animals per sex per dose:

5

Control animals:

not specified

Results and discussion

Effect levels

Effect levels 1

Sex:

not specified

Dose descriptor:

LC0

Effect level:

3.66 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

405 min

Remarks on result:

other: vapour generation temperature: 23-25°C

Effect levels 2

Key result

Sex:

not specified

Dose descriptor:

LC100

Effect level:

3.74 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

420 min

Remarks on result:

other: vapour generation temperature: 60C, cooled to room temperature prior to exposure

Any other information on results incl. tables

									Gross necropsy
Compound	Vapor generation temperature	Nominal Concentration		Expo. Dur.	Observations		Mortality			Survivors
					During Exposure	Post Exposure	During Expo.	Post Expo.	Deaths	1 Day	14 Days
	°C	mg/L	ppm	min.
Vinylbenzyl chloride B.P. = 228 °C 1 mg/L = 160.2 ppm	23-25	3.66	≈ 586	405	- Slight eyes and  nose irritation - slight labored breathing - lethargic	- Body weight loss for 4-5 days - One rat acquired lung rattle for approx. 1.5 weeks - Appreared normal at end of 2 weeks	0/5	0/5	--	no visible lesion	no visible lesion
	60	3.74	≈ 600	420	- slight eyes and nose irritation - slight labored breathing - lethargic	- Body weight loss - severe respiratory rales - fur stained yellow	0/5	5/5 (in 5 days)	- corneal damage - pulmonary congestion and hemorrhage	no visible lesion	--
	140	31.55	≈ 5050	255	- Eyes and nose irritation - Dyspnea - Prostration - Death		5/5	--	- Pulmonary edema	--	--

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

At a nominal concentration of 3.66 mg/L for 405 minutes of vinylbenzyl chloride no mortality occurred and no visible lesion. At 3.74 mg/L for 420 minutes all test animals died in 5 days after exposure and at a concentration of 31.55 mg/L and 255 minutes the animals died during exposure. The observed acute inhalative toxicity corresponds to Category 3. Eye and nose irritation is observed at every concentration.

Executive summary:

At a nominal concentration of 3.66 mg/L for 405 minutes of vinylbenzyl chloride no mortality occurred and no visible lesion. At 3.74 mg/L or 420 minutes all test animals died in 5 days after exposure and at a concentration of 31.55 mg/L and 255 minutes the animals died during exposure. The observed acute inhalative toxicity corresponds to Category 3. Eye and nose irritation is observed at every concentration.