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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Older study: meets scientific standards with acceptable restrictions (limited number of animals in study, partly limited documentation)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicology of the Citric Acid Esters: Tributyl Citrate, Acetyl Tributyl Citrate, Triethyl Citrate, and Acetyl Triethyl Citrate
Author:
Finkelstein M & Gold H
Year:
1959
Bibliographic source:
Toxicol Applied Pharmacol 1, 283 - 298
Reference Type:
study report
Title:
Unnamed
Year:
1959

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Study from 1959 (no guidelines available at the time the study was performed)
GLP compliance:
no
Remarks:
Study from 1959 (GLP was not compulsory at the time the study was performed)
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Triethyl O-acetylcitrate
EC Number:
201-066-5
EC Name:
Triethyl O-acetylcitrate
Cas Number:
77-89-4
Molecular formula:
C14H22O8
IUPAC Name:
triethyl 2-acetoxypropane-1,2,3-tricarboxylate

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
Single dosing with 5 - 15 mL/kg (ca. 5 - 15 g)
No. of animals per sex per dose:
Dosed was a group of 5 animals (no further details reported)
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 21 d
Frequency of observations and weighing: not reported
Necropsy of survivors performed: not reported
Other examinations performed: body weight,organ weights, histopathology
Statistics:
Not further specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 7 000 mg/kg bw
Mortality:
Deaths occured at any dose level throughout the study.
Clinical signs:
other: The signs included weakness, depression, ataxia, hyperexcitability, unrest, urinary dribbling, irregular and labored respiration, and in the advanced phase of poisoning convulsions appeared in some of the animals.
Gross pathology:
Not reported

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
In this older study with Wistar rats the LD50 was estimated with ca. 7000 mg/kg.
Executive summary:

In this older study Wistar rats were dosed once with 5 - 15 mL/kg (ca. 5000 - 15000 mg/kg) via gavage. All animals were observed for signs of toxicity for 21 d following dosing. The dosing caused no deaths and the estimated LD50 was given with 7 mL/kg (ca. 7000 mg/kg).