Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP study with limited information on test material, test animals, study design and clinical examination

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
limited test material, testing animal and study design information
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Naphthalene-1,5-disulphonic acid
EC Number:
201-317-9
EC Name:
Naphthalene-1,5-disulphonic acid
Cas Number:
81-04-9
Molecular formula:
C10H8O6S2
IUPAC Name:
naphthalene-1,5-disulfonic acid
Test material form:
solid: crystalline
Details on test material:
Unspecified test material

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
1500, 2000, 2200, 2500, 3100 and 5000 mg/kg bw
No. of animals per sex per dose:
10 males
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
2 420 mg/kg bw
Based on:
test mat.
95% CL:
2 200 - 2 710

Any other information on results incl. tables

Table 1: Mortality data

Dose [g/kg bw]

Time to death [days]

Mortality

Number of dead/total animals

1.5

-

0/10

2.0

3

1/10

2.2

2-3

4/10

2.5

2

7/10

3.1

2

8/10

5.0

3-6

10/10

Applicant's summary and conclusion

Executive summary:

Early study with acceptable scientific method. LD50: 2420 mg/kg (95th percentiles: 2200 -2710 mg/kg)