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Vapour pressure

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Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 November 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method. Test substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2009
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
Inspected on 13 and 14 October 2014 / Signed on 8 April 2015
Type of method:
static method
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
573 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
822 Pa

The calculation results are presented in the following table:

n

Temperature T

Pressure p

Temperature T

1/T

log p

 

°C

hPa

K

1/K

log Pa

1

20.0

5.2

293.15

0.00341122

2.7160

2

28.9

11.0

302.05

0.00331071

3.0414

3

38.0

21.6

311.15

0.00321388

3.3345

4

47.0

36.0

320.15

0.00312354

3.5563

5

55.0

48.7

328.15

0.00304739

3.6875

6

46.0

34.6

319.15

0.00313332

3.5391

7

37.0

20.6

310.15

0.00322425

3.3139

8

28.0

9.8

301.15

0.00332060

2.9912

9

21.0

6.7

294.15

0.00339963

2.8261

10

16.0

4.0

289.15

0.00345841

2.6021

The parameters for the linear regression of the graph log (p) vs. 1/T are presented in the following table:

Parameter

Value

Slope

-2738.958416

Intercept

12.10156734

Correlation coefficient r

-0.99524888

Coefficient of determination r2

0.990520333

Vapour pressures at ambient temperature were calculated as:

Parameter

Value

Unit

Vapour Pressure (20 °C)

573

Pa

Vapour Pressure (25 °C)

822

Pa

Conclusions:
Ten pairs temperature/vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be estimated.
From the measured values, the vapour pressure of the test item was calculated as 573 Pa at 20.0 °C and 822 Pa at 25 °C. The values of the heating and cooling down phase showed good correspondence.
Executive summary:

The study was performed in order to determine the vapour pressure of test item according to OCED 104, resp. EU A.4 guideline, using the static method.

From the measured values, the vapour pressure of the test item was calculated as 573 Pa at 20.0 °C and 822 Pa at 25 °C.

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 November 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method. Test substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2009
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
Inspected on 13 and 14 October 2014 / Signed on 8 April 2015
Type of method:
static method
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
511 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
706 Pa

The calculation results are presented in the following table:

n

Temperature T

Pressure p

Temperature T

1/T

log p

 

°C

hPa

K

1/K

log Pa

1

20.0

5.0

293.15

0.00341122

2.6990

2

28.9

9.0

302.05

0.00331071

2.9542

3

38.1

17.3

311.25

0.00321285

3.2380

4

47.0

25.8

320.15

0.00312354

3.4116

5

56.0

44.8

329.15

0.00303813

3.6513

6

48.0

24.9

321.15

0.00311381

3.3962

7

39.1

15.0

312.25

0.00320256

3.1761

8

30.0

9.9

303.15

0.00329870

2.9956

9

21.0

6.4

294.15

0.00339963

2.8062

10

16.0

3.5

289.15

0.00345841

2.5441

The parameters for the linear regression of the graph log (p) vs. 1/T are presented in the following table:

Parameter

Value

Slope

-2453.915043

Intercept

11.07952542

Correlation coefficient r

-0.993756131

Coefficient of determination r2

0.987551247

Using the equation which is stated in chapter9, vapour pressures at ambient temperature were calculated as:

Parameter

Value

Unit

Vapour Pressure (20 °C)

511

Pa

Vapour Pressure (25 °C)

706

Pa

Conclusions:
The vapour pressure of test item was measured using the static method as described in OECD 104 resp. EU A.4.
Ten pairs temperature/vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be estimated.
From the measured values, the vapour pressure of the test item was calculated as 511 Pa at 20.0 °C and 706 Pa at 25 °C.
The values of the heating and cooling down phase showed good correspondence.
Therefore, the result of the study is considered valid.
Executive summary:

The study was performed in order to determine the vapour pressure of test item according to OCED 104, resp. EU A.4 guideline, using the static method.

The vapour pressure of test item was calculated as 511 Pa at 20°C and 706 Pa at 25°C.

Description of key information

The vapour pressure of test item was calculated to be between 511 and 573 Pa at 20°C and between 706-822 Pa at 25°C.

Key value for chemical safety assessment

Additional information

Two fully reliable experimental studies, conducted according to OECD 104 /EU A4 guideline, using static method, are available.

Both are considered as a key study, and the result is retained as key data.