Registration Dossier
Registration Dossier
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EC number: 600-254-8 | CAS number: 10195-54-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1995
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 1989
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- 1992
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- titration method
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.4
- Temp.:
- 25 °C
- Remarks on result:
- other: rough estimation
- Conclusions:
- The partition coefficient was calculated to be: log Pow = -0.4
- Executive summary:
Neither the HPLC-method according to OECD Guideline No. 117 nor the flask-shaking method according to OECD Guideline No. 107 were applicable for the determination of the partition coefficient of the test item. Thus, the log Pow-value for the test item was estimated from its solubility in n-octanol and in water, respectively. In the present study, the n-octanol solubility of the test item was estimated to be at least 40 g/L. The water solubility of the test article was estimated to be 100 g/L (or above) in the water solubility test. Thus, the partition coefficient, log Pow, of the test item was calculated to be -0.4.
Reference
Description of key information
The partition coefficient was determined to be log Pow = -0.4
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.4
- at the temperature of:
- 25 °C
Additional information
Neither the HPLC-method according to OECD Guideline No. 117 nor the flask-shaking method according to OECD Guideline No. 107 were applicable for the determination of the partition coefficient of the test item. Thus, the log Pow-value for the test item was estimated from its solubility in n-octanol and in water, respectively. In the present study, the n-octanol solubility of the test item was estimated to be at least 40 g/L. The water solubility of the test article was estimated to be 100 g/L (or above) in the water solubility test. Thus, the partition coefficient, log Pow, of the test item was calculated to be -0.4.
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