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Diss Factsheets

Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 to 27 October 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
modified according to Letinski et al. (2002) and OECD 123 (2006)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
modified according to Letinski et al. (2002) and OECD 123 (2006)
GLP compliance:
yes (incl. QA statement)
Remarks:
Staatliches Gewerbeaufsichtsamt Hildesheim, Germany
Type of method:
flask method
Remarks:
flask method with slow stirring approach
Key result
Water solubility:
361 mg/L
Incubation duration:
> 76 h
Temp.:
20 °C
pH:
5

Test Temperature during the Incubation Phase and the Definitive Testing (measured hourly)

Intended temperature

[°C]

Measured temperature

[°C]

 

Replicate 1

Replicate 2

20.0 ± 0.5

Min.

20.00

19.96

Max.

20.09

20.06

Mean value

20.03

19.99

SD ±

0.01

0.02

Min = Minimum temperature measured

Max = Maximum temperature measured

SD = Standard deviation

 

Check of the pH-value

Replicate

pH-Value

Mean

1

5.058

5.0

2

4.964

 

Check of the Tyndall-Effect

All samples were checked negative for a Tyndall effect verifying the absence of colloidal dispersed matter.

 

Solubility Results: Water Solubility Results at 20 °C

Sampling of equilibrium

Incubation time (1)

[h]

Calculated Concentration (2)

[mg/L]

 

Replicate 1

Replicate 2

1 *

72.57

318

346

2 *

74.58

313

342

3 *

76.66

318

348

4

94.83

351

374

5

96.83

348

372

6

98.99

350

375

7

118.99

351

371

8

120.99

347

371

9

122.99

347

371

Overall

 

Mean

349

373

361

 

Deviation [%]

1.1

0.9

6.8

(1) = Time after application

(2) = Dilution factor of 10 and exact weight of the external standard taken into account

* = Not taken into account, as equilibrium was not achieved

 

 

Conclusions

The water solubility of the test substance was determined at 20 °C and pH 5.0 to be 361 mg/L.

Conclusions:
A water solubility value of 361 mg/L (at 20 °C, pH = 5.0) was determined for the test substance according to OECD 105. modified according to Letinski et al. (2002) and OECD 123 (2006)

Description of key information

Water solubility: 361 mg/L at 20 °C, pH = 5.0 (EU Method A.6, slow stirring method)

Key value for chemical safety assessment

Water solubility:
361 mg/L
at the temperature of:
20 °C

Additional information